Herramientas de Accesibilidad
The man in his different productive processes has generated modifications to the environment. Metallurgical mining is not exempt from this, since many of the waste produced, especially effluents, does not have any type of treatment before being dumped. The objective of the research was to evaluate the efficiency of removal of Cu, Fe and Pb from the mining-metallurgical effluent on a laboratory scale by applying a bioadsorbent filter with lignocellulosic fibers (banana, coconut and orange peels). 10 filters composed of banana, coconut and orange peels were designed in different proportions (100 gr being 100%), as established by the Simplex Lattice Mix Design, with three metals to be removed (Cu, Fe and Pb). We worked at pH 7.3, contact time of 3 hours and particle size of 0.250 mm, in all treatments. The results show that for Cu the best treatment was (T2), with 100 gr of coconut shells (96.36%); for iron, treatment six (T6) composed of coco-orange (50 gr of each) with an efficiency of (92.05%); and the lead showed a greater removal of 97.34% with treatments three (T3) and six (T6) composed of 100 grams of orange and coco-orange (50 grams of each), respectively. The data were better adjusted to the special cubic regression model, with the P value of 0.000305 being copper and the coefficient of determination R2 0.790156. For iron, the P value 0.000000 and determination coefficient R2 0.930029. The P value of lead was 0.000034 and the coefficient of determination R2 0.719867. Considering that the value of R2 is better the closer it gets to 1, and that (p <0.05) is significant.
Aibi, Revista de Investigacion Administracion e Ingenierias
Opsiphanes cassina is the most common defoliating pest in the country\'s commercial oil palm plantations, being responsible for low yields and the disappearance of large numbers of hectares of cultivation. The objective of this work was to evaluate in laboratory the invasive capacity of two formulations (powder and liquid presentation) based on Beauveria bassiana on the insect Opsiphanes cassina. Microbiological quality control tests showed germination percentages of B. bassiana spores for the solid formulation of 90% while in the liquid they were 97.7%. 100% purity was achieved for both formulations and the concentration of spores was 4.9x1010 spores/ml in the solid formulation and 8.6x1010 spores/ml in the liquid formulation. Concluding that the liquid formulation causes greater mortality in a smaller time (6 days) on the larvae of the III instar, being feasible its production and commercialization.
Aibi, Revista de Investigacion Administracion e Ingenierias
The biodiesel production was analyzed by chemical and enzymatic processes, from used cooking oil (UCO), evaluating the quality and yield of the product obtained in each method. For the chemical process, an acid esterification followed by a basic transesterification was developed, (reaction temperature: 60 °C, oil:methanol 1:6 molar ratio, concentration of KOH catalyst: 1% w/w reaction times: 55 and 70 min); and enzymatic transesterification (temperature: 38 °C, oil:methanol 1:3 molar ratio, enzyme concentration lipase XX 25 split liquid: 5%, reaction times: 3 and 6 hours). Physicochemical properties (i.e. density, kinematic viscosity, moisture content, fatty acid profile, percentage of acidity, peroxides index and saponification) of the raw material were determined. Results showed the presence of oleic acid (42.45%) and palmitic acid (33.52%). The highest yield obtained was from the chemical transesterification under the conditions of 60 °C, 1% KOH and 70 min with a conversion percentage of 96.15% and an acid number of 1.33 mmKOH/g, compared to the enzymatic transesterification which registered a high acid number of 6.91 mmKOH/g and conversion percentage of 48.81% under the conditions of 38 °C, 5% of enzyme lipase and 3 hours.
Aibi, Revista de Investigacion Administracion e Ingenierias
The responsibility of nursing professionals in prenatal control is highly compromising, if we take into account that Resolution 0412 of 2000, which establishes that nursing consultation can only be performed by a nurse (or) professional being the only one within the promotion and prevention programs that is catalogued in this way; thus being the professional nurse the axis so that prenatal control is developed with quality and opportunity, fulfilling the parameters established in the care guide of the Ministry of Health. The prenatal control is the main tool that the institutions have to guarantee a supervised gestation, and thus to achieve that the childbirth and the birth occur in conditions of quality, without biological or psychological consequences for the binomial mother-child. The main objective of this research was to analyze the biopsychosocial risk in pregnant women who attended the prenatal control appointment of the La Libertad Maternal and Infant Basic Unit, in which a descriptive quantitative study was used, where a sample of 48 pregnant women with no more than 18 weeks of gestation who attended in January, February and March 2018 was taken, which were applied the scale for the biopsychosocial risk assessment. In the analysis of the results of the scales applied, the following factors were presented with greater prevalence: bad character, high tension headache, crying, insomnia, depression, nervousness and muscular tension.
Aibi, Revista de Investigacion Administracion e Ingenierias
Humanized care must be the result of the disciplinary interrelationship between knowledge and action, in order to provide affective and effective care to the patient. For this reason, it is considered important to evaluate the conditions in which care is offered, the attitudes of nursing staff towards patients and family, as a basis for qualitative analysis of the quality of service offered during the application of medical procedures. The qualitative work was developed with nursing students from the 4th to the 9th semester of the University of Santander, Cúcuta - Colombia, where through observation and interviews the bases of the analysis were established, the objective of the research. It is evident the good perception that the students have during their formation, being integrally educated by the teachers as for the humanized care and in this way applying what they learned in the formative practice, standing out as integral students. Likewise, they assertively describe the concept of humanization, specifying that humanization is the series of cares that nursing provides to the patient in his physical and mental state, worrying not only about the scientific procedures but also about the accompaniment, the listening, the environment and the dialogue with the patient and his family. Finally, they affirmed that they have had experiences in their formative practices that have marked their life as professionals, where they have learned to place themselves in the place of the other and not only to have the vision of a patient, but also to see him as a human being who feels, who suffers and who needs, in addition to receiving treatment, to receive integral care to achieve his recovery.
Aibi, Revista de Investigacion Administracion e Ingenierias
This article presents a dissertation on philosophy as the manager of the science, technology and innovation triad, which will make use of information gathering in educational and organizational psychology in order to disseminate the process of the abstract to the factual.
Aibi, Revista de Investigacion Administracion e Ingenierias
The evolutionary and ecological study of tolerance to herbivory has been centered in its operational definition. In spite of the critical role of the operational definition of tolerance that has permitted its evolutionary modeling, a causal understanding of its mechanisms that allow a universal approximation to look for difference across populations and species is mandatory. The author proposes a research program for tolerance mechanisms whose focus is not to produce long-term predictions of its evolutionary change but to determine the causes and objects of selection. The reward for this study framework is a more precise understanding of the adaptations driving by herbivory, in contrast to other selective pressures behind the evolution of tolerance lineages. Additionally, it can throw much light on the possibility that specific tolerance mechanisms within plant groups affect plant-herbivore coevolution by imposing selection on herbivores.
Evolutionary Ecology of Plant-Herbivore Interaction
International Journal of Surgery Open
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
Nature
INTRODUCTION: A frequent cause of weaning and extubation failure in critically ill mechanically ventilated patients is diaphragm muscle dysfunction. Ultrasound (US) evaluation of the diaphragm yields important data regarding its thickness (diaphragm thickening fraction [TFdi]) and its movement or excursion (diaphragmatic dynamics) that reveal the presence of diaphragmatic dysfunction. METHODS: Cross-sectional study, which included patients older than 18 years with invasive mechanical ventilation with an expected duration of more than 48 h, in a tertiary referral center in Colombia. The excursion of the diaphragm, inspiratory and expiratory thickness, and TFdi were evaluated by US. Prevalence and use of medications were evaluated, and the association with failure in ventilatory weaning and extubation was analyzed. RESULTS: Sixty-one patients were included. The median age and APACHE IV score were 62.42 years and 78.23, respectively. The prevalence of diaphragmatic dysfunction (assessed by excursion and TFdi) was 40.98%. The sensibility, specificity, positive predictive value, and negative predictive value for TFdi < 20% was 86%, 24%, 75%, and 40%, respectively, with an area under the receiver operating characteristic (ROC) curve of 0.6. The ultrasonographic analysis of excursion of the diaphragm, inspiratory and expiratory thickness, and TFdi (>20%) allow in its set and with normal values, predict success or failure for the extubation with an area under the ROC curve of 0.87. CONCLUSION: Diaphragmatic dynamics and thickness parameters together assessed by ultrasonography could predict the success of extubation in critically ill patients in Colombia, based on the finding of diaphragmatic dysfunction.
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine
During the processing of poultry, disinfectants are commonly added to cooling water tanks called “chillers” to reduce microorganism populations that can affect food quality. The present study, evaluated the effectiveness of neutral electrolyzed water in a pilot-project-sized chiller for the elimination of pathogenic microorganisms in gizzards and necks chicken. The microbiological analysis of the samples was processed and analyzed in three different food microbiological analysis laboratories. The results demonstrated a maximum microbial load reduction of 1.97686 log CFU/g for Escherichia coli and 1.76313 log CFU/g for Staphylococcus aureus in all samples processed with neutral electrolyzed water. Sodium hypochlorite, a disinfectant in common industrial use, did not achieve significant reductions in microbial loads below those of untreated necks and gizzards for either of the microorganisms in question. Based on these results, this study thus proposes the use electrolyzed water as an alternative disinfectant to sodium hypochlorite for use in chillers; being a sustainable solution that differs from conventional disinfectants in its lack of human or environmental side effects.
Energy Nexus
The case study is developed with the aim of improving the current evaluation tool for decision-making in the Fiuidacion Valor y Compromiso (V&C). with the support of process leaders who provided iiiforniation through the application of a survey,this technique allowed to obtain a diagnosis of the company regarding the use of the current tool. Subsequently, the selection of the most significant management indicators in each process and the design of their respective technical sheet were carried out. Then, the results obtained for the year 2019 were consolidated into a comprehensive evaluation instrument. In the next stage, a pilot test was implemented for the process leaders, which are responsible for monitoring and controlling the management indicators, measuring the performance of each indicator through the qualification obtained concerning a projected goal. In this way, the assessment tool contributes to the continuous improvement of the organization, and connotes itself as an instrument for planning and reviewing activities. Likewise, This tool facilitates decision-making on preventive and corrective actions in processes that have low or high performance, improving the most critical processes such as commercial management and social management, and maintaining the best-perfonning processes such as legal, contracting and purchases, according to the results obtained in the pilot test carried out.
Aibi, Revista de Investigacion Administracion e Ingenierias
During the COVID-19 pandemic, the Colombian government failed to report statistics systematically separated by ethnicity. Moreover, municipalities with the highest proportion of indigenous populations have some of the highest hospitalization and death rates from COVID-19. Community self-organization in indigenous territories has strengthened community networks based on solidarity and reciprocity, thus managing individual and collective risks in regions neglected by public administrations. The Colombian National Indigenous Organization (ONIC) has systematically published a bulletin to analyze the National Institute of Health Information with data regarding the location of COVID-19 cases among indigenous communities, collected by diverse indigenous organizations. The ONIC has deployed territorial health actions nationwide and mobilized more than 60, 000 indigenous guards to form a sanitary cordon, accompanied by their traditional medicine and spiritual practices. Despite the high morbidity and mortality levels resulting from preexisting inequities, indigenous individuals organized in networks have maintained food sovereignty with reciprocity and solidarity practices. In contrast, government agencies have significant limitations in attending to the emergency, deepening social inequalities among vulnerable populations. The current pandemic provides an opportunity to recognize indigenous peoples’ ancestral knowledge, including how they conceive health in an interconnected natural network. This chapter analyzes indigenous community networks as being necessary for the present and future to enhance population health. Thus, public health planning and social work could benefit by incorporating complex indigenous thinking to develop planetary intercultural health and well-being.
The Coronavirus Crisis and Challenges to Social Development: Global Perspectives
A large number of the parasitic agents that alter the health of swine could be spread to humans, especially in backyard conditions, and, many times, cause difficulties in public health and food security. This investigation was conducted to determine the seroprevalence and risk factors associated with swine cysticercosis and Trichinella spiralis in backyard pigs in the Bucaramanga province of Colombia. A total of 380 serum samples were used for the search for Tr. spiralis and Tenia solium antibodies using the ELISA technique. The seroprevalence of T. solium cysticercosis infection was 40.5%, whilst anti-Tr. spiralis antibodies were not observed in the processed samples. Regarding risk factors, free-ranging pigs and non-dewormed pigs showed almost 3 (OR=2.9; P < 0.05) and 2.7 (OR=2.7; P < 0.05) times more risk of presenting antibodies against T. solium cysticercosis, respectively. The seroprevalence of swine cysticercosis found in this investigation can be caused by low-quality housing and poor hygiene, increasing the spread of this zoonotic parasite infection among swine and humans. No positive samples for Tr. spiralis were observed. The variables access to latrines and deworming of pigs were presented as the risk of infection for cysticercosis by T. solium, this could increase the probability of infection risk of parasites with zoonotic potential between pigs and humans.
Archives of Veterinary Science
Introduction: Essential oils are a complex mixture of compounds with numerous industrial uses. Among the aromatic plants with medicinal value, Thymus vulgaris L. is a perennial subshrub of the family Lamiaceae, used as a flavoring and preservative with antiseptic and antimicrobial activity. Salmonella spp. is a gram-negative enteropathogen that causes salmonellosis, a foodborne disease with a notorious increase in recent years. Objective: To study the chemical composition and antibacterial activity of essential oils of Thymus vulgaris L on Salmonella enteritidis ATCC 17036 and Salmonella paratyphi A ATCC 9150. Methods: Two essential oils of Thymus vulgaris L were used: one imported, product of the flowers of Thymus vulgaris and Thymus zygis and another experimental oil obtained from the leaves, flowers and stems of Thymus vulgaris. Presumptive identification of the compounds was performed by gas chromatography coupled to mass spectrometry. For preliminary antimicrobial activity, the agar diffusion method and the broth macrodilution method were used to obtain the minimum inhibitory concentration and the minimum bactericidal concentration. Results: In the commercial oil, 19 components were fully identified, the major ones were thymol (45.3 %) and p-cymene (30.3 %); while in the experimental one, 33 components were found and 32 (97 %) were fully identified, being p-cymene (43.8 %) the most predominant. The commercial sample exhibited inhibition of Salmonella paratyphi A at 4.625 mg/mL with respect to eEO which required 5.5 mg/mL to inhibit Salmonella enteritidis. Conclusions: Chemically, differences were observed in the compounds present in the oils studied, which may be related to the part of the plant used to obtain them. Both Salmonella species showed susceptibility at relatively low concentrations with respect to the reported toxic dose, which catalogs the essential oil of Thymus vulgaris as a potential biotherapeutic.
Revista Cubana de Farmacia
Introduction The Susceptible-Exposed-Infected-Recovered (SEIR) mathematical-epidemiological model has been exhaustively used since de beggining of the COVID-19 pandemic. These models intended to predict hospital burden and evaluate health measures to contain its spread. In this sense, flaws have been evidenced in the predictions of the first published models. It is considered necessary to evaluate the differences in the approach and verification of the models. Objectives Categorize the scientific publications of high-impact journals that proposed SEIR-type models to represent the COVID-19 pandemic in its early days. Methods We carried out a systematic review of the articles published in journals indexed in the Web of Science, of the first quartile and with an impact factor greater than two, that met the selection and inclusion criteria following the PRISMA-ScR standards. We included a total of 32 articles, which were evaluated according to demographic characteristics such as the month of receipt and publication, the country of origin of the information, the subject matter of the journal, and the characteristics of the modeling such as the presence of additional compartments, graphical analysis, conceptual model approach, interpretation of the basic reproductive number, and estimation of parameters. Results Articles published in medical and health journals were predominant from February to July 2020. These articles most frequently used data from China and mostly focused on SEIR or full quarantine compartment models. The articles published in journals in mathematics were predominant from August to December 2020. Models used data from different world regions, considering a greater diversity of compartments such as asymptomatic patients or partial or complete quarantine. Conclusions The articles analyzed mostly use SEIR-type models expanded with additional compartments. There are discrepancies in the breadth and methodological quality of the articles published according to the journal’s subject matter. The unification of quality criteria for describing the models in any journal is recommended.
Medwave
This study provides an in-depth analysis of the potential role of hydrogen (H2) in the Belgian transport sector in the context of sustainable and environmentally friendly growth. This paper starts by examining the energy-climate roadmap and the emission mitigation programme defined by the Belgian federal government in the context of environmental sustainability. Then, the Belgian situation is critically evaluated in light of the needs for H2 fuel in the transport sector, as well as issues about a roadmap on environmental considerations for a sustainable future, while preserving the country\'s economic stakes. There are several key advances in this direction, especially as H2 is seen as one of the best viable options for sustained development, unlike other possibilities. This paper also highlights some limitations that make it difficult to accelerate the transition to a sustainable H2 energy future. Although there are many interests in favour of an advanced and non-polluting transport system, there are differing views on the approach to be taken in political decision-making at national level. Therefore, this study will help public authorities to better integrate environmental and sustainability issues in the context of a transition to a comprehensive hydrogen economy in the current transport sector.
International Journal of Hydrogen Energy
Animal-source foods (ASF) provide nutrition for children and adolescents’ physical and cognitive development. Here, we use data from the Global Dietary Database and Bayesian hierarchical models to quantify global, regional and national ASF intakes between 1990 and 2018 by age group across 185 countries, representing 93% of the world’s child population. Mean ASF intake was 1.9 servings per day, representing 16% of children consuming at least three daily servings. Intake was similar between boys and girls, but higher among urban children with educated parents. Consumption varied by age from 0.6 at <1 year to 2.5 servings per day at 15–19 years. Between 1990 and 2018, mean ASF intake increased by 0.5 servings per week, with increases in all regions except sub-Saharan Africa. In 2018, total ASF consumption was highest in Russia, Brazil, Mexico and Turkey, and lowest in Uganda, India, Kenya and Bangladesh. These findings can inform policy to address malnutrition through targeted ASF consumption programmes.
Nature Food
The global burden of diet-attributable type 2 diabetes (T2D) is not well established. This risk assessment model estimated T2D incidence among adults attributable to direct and body weight-mediated effects of 11 dietary factors in 184 countries in 1990 and 2018. In 2018, suboptimal intake of these dietary factors was estimated to be attributable to 14.1 million (95% uncertainty interval (UI), 13.8–14.4 million) incident T2D cases, representing 70.3% (68.8–71.8%) of new cases globally. Largest T2D burdens were attributable to insufficient whole-grain intake (26.1% (25.0–27.1%)), excess refined rice and wheat intake (24.6% (22.3–27.2%)) and excess processed meat intake (20.3% (18.3–23.5%)). Across regions, highest proportional burdens were in central and eastern Europe and central Asia (85.6% (83.4–87.7%)) and Latin America and the Caribbean (81.8% (80.1–83.4%)); and lowest proportional burdens were in South Asia (55.4% (52.1–60.7%)). Proportions of diet-attributable T2D were generally larger in men than in women and were inversely correlated with age. Diet-attributable T2D was generally larger among urban versus rural residents and higher versus lower educated individuals, except in high-income countries, central and eastern Europe and central Asia, where burdens were larger in rural residents and in lower educated individuals. Compared with 1990, global diet-attributable T2D increased by 2.6 absolute percentage points (8.6 million more cases) in 2018, with variation in these trends by world region and dietary factor. These findings inform nutritional priorities and clinical and public health planning to improve dietary quality and reduce T2D globally.
Nature Medicine
Autoimmune pathologies are conditions caused by an abnormal response of the immune system. Systemic sclerosis is an autoimmune disorder that affects the microvasculature of the gastrointestinal tract, lungs, kidneys, heart, skin and joints, with consequent fibrosis of the affected organs, while systemic lupus erythematosus is characterized by an aberrant activity of the immune system considered as a prototype of immune complex-mediated disease, leading to variable clinical symptoms; the overlap of two pathologies of the immune system is unusual, without mentioning the mixed connective tissue disease, and it is of great importance to identify a combined pathology since it has a great impact on the clinical characteristics, diagnosis, treatment and prognosis of the patient.
Gaceta Medica Boliviana
Human immunodeficiency virus (HIV) is nowadays one of the major health problems worldwide. Several strategies have been explored for the eradication of latent HIV-1 reservoirs, current antiretroviral therapy stops the progression of HIV disease, however, as new therapies are being developed, CRISPR (clustered regularly interspaced short palindromic repeats) systems have recently been used as a genome editing technique. CRISPR is becoming progressively one of the possible cures, although it remains experimental, for HIV in medical research. This systematic review summarizes literature evidence of CRISPR gene editing in HIV/AIDS therapy. This study also identifies the research gaps in the current literature, helping to guide future research.
Gaceta Medica de Caracas
ABSTRACT: Spyrou, K, Alcaraz, PE, Marín-Cascales, E, Herrero-Carrasco, R, Cohen, DD, and Freitas, TT. Neuromuscular performance changes in elite futsal players over a competitive season. J Strength Cond Res 37(5): 1111-1116, 2023-A professional futsal season imposes a great amount of physiological and mechanical stress on players. The main aim of this study was to examine the changes in neuromuscular performance qualities across the season. Ten professional male players performed a 10-m sprint, standing long jumps (SLJs), and countermovement jumps (CMJs) during the competitive season (i.e., every ∼5 weeks from September to January). A one-way repeated measures ANOVA with post hoc pairwise comparisons and effect sizes (ESs) were used to analyze potential differences among these assessments. A significant and large decline was found in concentric peak power ( p = 0.040; ES = 1.24). A nonsignificant and moderate decrease was observed in sprint ability ( p = 0.155; ES = 1.03), CMJ height ( p = 0.175; ES = 1.00), and SLJ distance ( p = 0.164; ES = 1.03). Regarding other CMJ kinetic variables, nonsignificant and moderate changes were found. In summary, considering the neuromuscular performance tests and variables assessed, only concentric peak power in CMJ decreased significantly across the season; however, nonsignificant decrements were observed in sprinting time, SLJ, CMJ height, and other kinetic metrics. CMJ variables during the jump-land cycle should be incorporated alongside more traditional measures (e.g., jump height) to monitor performance during the season.
Journal of strength and conditioning research
Introduction: The WHO reports an increase in chronic non-communicable diseases. Given the complexity of these diseases, patients are constantly hospitalized; therefore, it is necessary to strengthen the competence of both patients and caregivers at home to take care of the disease using the program \"discharge plan.\" Objective: To determine the change in care competency following the implementation of the tool \"discharge plan\" in a second-level care facility for in-home care of the chronically ill person and family caregiver dyad. Materials and Methods: Quantitative, quasi-experimental study, with pre-test and post-test design, using the \"Characterization of the patient-caregiver dyad\" form and the \"CUIDAR\" instrument. The population consisted of 62 dyads. Non-probabilistic convenience sampling was used. Pre- and post-delta was calculated, and paired Student t-test was used for comparison. Results: The \"discharge plan\" program increased the patients\' dimensions of Knowledge by a delta of 3.2, Uniqueness by 3.0, and total care competency by 10.3. Family caregivers\' competencies improved in the dimensions of Knowledge by a delta of 3.34, Uniqueness by 1.5, Enjoyment by 1.7, and Reciprocityrelationship by 1.61, for a total competency score of 9.2. Discussion and conclusions: These findings suggest that the discharge plan program must be strengthened during hospitalization and discharge to improve the homecare competency of chronically ill patients and their family caregivers.
Revista Cuidarte
Aims The International Polycap Study 3 (TIPS-3) trial demonstrated that a polypill containing cholesterol- and multiple blood-pressure-lowering drugs reduces cardiovascular events by 20% compared with placebo in people without cardiovascular disease. The polypill plus aspirin led to a 31% relative risk reduction in cardiovascular disease events compared with double placebo. We report regional variations in costs and affordability of a polypill based on the TIPS-3 trial. Methods and results Countries were categorized using World Bank economic groups: lower-middle-income, upper-middle-income, and high-income countries. Country-specific costs were obtained for hospitalization events, procedures, and non-study medications (2019 US dollars). Polypill price was based on the cheapest equivalent substitute (CES) for each component. For the polypill vs. placebo, the difference in cost over the 4.6 years of the trial was $291 [95% confidence interval (CI): $243–339] per participant in lower-middle-income countries, $1068 (95% CI: $992–1144) in upper-middle-income countries, and $48 (95% CI: −$271 to $367) in high-income countries. Results were similar for the polypill plus aspirin vs. a double placebo. In both cases, the polypill was affordable in all groups using monthly household capacity to pay or a threshold of 4% of the gross national income per capita. Conclusion The use of a polypill (CES) in TIPS-3 increases costs in lower-middle-income countries and upper-middle-income countries but is affordable in countries at various economic levels and is cost neutral (dominant) in high-income countries.
European Heart Journal - Quality of Care and Clinical Outcomes
The Colombian manufacturing industry has low levels of innovation, this may be due to factors such as low capacity to innovate, learn and adapt to the environment, among which there may be a relationship that is little studied. Therefore, the main objective of this article is to approach the joint influence of learning and adaptation capacity on the capacity to innovate in Colombian industrial companies. For this, 1,571 companies registered in the Industrial Technological Development and Innovation Survey 2017-2018 were analyzed, through a non-experimental, cross-sectional, descriptive and correlational-causal design, using correlation and logit regression models. The main results allow us to understand that individually the capacity for learning and adaptation positively influence the probability of developing the capacity for innovation. The study manages to conclude that the joint existence of these two dynamic capacities partially enhances the development of the capacity for innovation
Revista de Ciencias Sociales
Universidad de Santander UDES. Vigilada Mineducación.
Resolución otorgada por el Ministerio de Educación Nacional: No. 6216 del 22 de diciembre de 2005 / Personería Jurídica 810 de 12/03/96.
Institución sujeta a inspección y vigilancia por el Ministerio de Educación Nacional. Resolución 12220 de 2016.
Notificaciones administrativas y judiciales:
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