Título del artículo:

Exosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms

The tumor microenvironment is made up of a universe of molecular and cellular components that promote or inhibit the development of neoplasms. Among the molecular elements are cytokines, metalloproteinases, proteins, mitochondrial DNA, and nucleic acids, within which the ncRNAs: miRNAs and lncRNAs stand out due to their direct modulating effects on the genesis and progression of various cancers. Regarding cellular elements, the solid tumor microenvironment is made up of tumor cells, healthy adjacent epithelial cells, immune system cells, endothelial cells, and stromal cells, such as cancer-associated fibroblasts, which are capable of generating a modulating communication network with the other components of the tumor microenvironment through, among other mechanisms, the secretion of exosomal vesicles loaded with miRNAs and lncRNAs. These ncRNAs are key pieces in developing neoplasms since they have diverse effects on cancer cells and healthy cells, favoring or negatively regulating protumoral cellular events, such as migration, invasion, proliferation, metastasis, epithelial-mesenchymal transition, and resistance to treatment. Due to the growing number of relevant evidence in recent years, this work focused on reviewing, analyzing, highlighting, and showing the current state of research on exosomal ncRNAs derived from cancer-associated fibroblasts and their effects on different neoplasms. A future perspective on using these ncRNAs as real therapeutic tools in the treatment of cancer patients is also proposed.

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Frontiers in Cell and Developmental Biology

Título del artículo:

Evaluation of mineral oils as matrices for AISI/SAE–1020 steel naphthenic corrosion study

Petrochemical industry has suffered great economic impact due to light crude oil reserves reduction, so refineries have been processing high acidity heavy crude oils. Studies of corrosion caused by naphthenic acids are interfered by presence of other corrosive agents contained in real crude oils, so naphthenic phenomenon must be isolated using synthetic crude oils. For this reason, in present work two high purity mineral oils were used to evaluate their efficiency as synthetic crude oil matrices in AISI/SAE–1020 steel naphthenic corrosion study. Temperature levels evaluated were 200 °C, 250 °C, and 300 °C, while exposure times evaluated were 5, 10 and 15 hours. Surface morphological characterization of AISI/SAE–1020 steel was carried out using scanning electron microscopy and X–ray diffraction. Gravimetric tests showed that AISI/SAE–1020 steel naphthenic corrosion rate increases with temperature and exposure time for one of the synthetic crude oils. However, results obtained for the other synthetic crude oil did not show increasing behaviour due to presence of sulfur traces in the oil, which caused an interference with AISI/SAE–1020 steel naphthenic corrosion study, reducing the reliability of gravimetric results so they cannot be extrapolated to operating conditions in distillation units.

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Journal of Physics: Conference Series

Título del artículo:

Left posterior fascicular ventricular tachycardia in a structurally healthy heart

We present the case of a 26-year-old patient with a history of psychoactive substance use who was admitted to the emergency room due to palpitations. In the electrocardiogram performed, tachycardia is observed repolarization alterations with inversion of T waves, which make suspect the presence of previous arrhythmia, without response to the initial management with antiarrhythmic and cardioversion, later a left posterior fascicular ventricular tachycardia is documented which she was managed with verapamil with total remission of symptoms and return to sinus rhythm. An infrequent form of ventricular tachycardia that usually occurs in patients without structural heart disease is presented, of clinical diagnostic importance for its timely treatment.

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Atencion Primaria Practica

Título del artículo:

Secondary chemical pneumonitis due to inhalation of organic solvents

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Atencion Primaria Practica

Título del artículo:

Spontaneous pneumotorax in a professional swimmer

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Atencion Primaria Practica

Título del artículo:

Immunomodulation and antioxidant activities as possible trypanocidal and cardioprotective mechanisms of major terpenes from lippia alba essential oils in an experimental model of chronic chagas disease

In the late phase of Trypanosoma cruzi infection, parasite persistence and an exaggerated immune response accompanied by oxidative stress play a crucial role in the genesis of Chronic Chagasic Cardiomyopathy (CCC). Current treatments (Benznidazole (BNZ) and Nifurtimox) can effect only the elimination of the parasite, but are ineffective for late stage treatment and for preventing heart damage and disease progression. In vivo trypanocidal and cardioprotective activity has been reported for Lippia alba essential oils (EOs), ascribed to their two major terpenes, limonene and caryophyllene oxide. To investigate the role of antioxidant and immunomodulatory mechanisms behind these properties, chronic-T. cruzi-infected rats were treated with oral synergistic mixtures of the aforementioned EOs. For this purpose, the EOs were optimized through limonene-enrichment fractioning and by the addition of exogenous caryophyllene oxide (LIMOX) and used alone or in combined therapy with subtherapeutic doses of BNZ (LIMOXBNZ). Clinical, toxicity, inflammatory, oxidative, and parasitological (qPCR) parameters were assessed in cardiac tissue. These therapies demonstrated meaningful antioxidant and immunomodulatory activity on markers involved in CCC pathogenesis (IFN-γ, TNF-α, IL-4, IL-10, and iNOS), which could explain their significant trypanocidal properties and their noteworthy role in preventing, and even reversing, the progression of cardiac damage in chronic Chagas disease.

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Antioxidants

Título del artículo:

Global outcomes, surgical teams and COVID-19 pandemic: Will the same objectives of global surgery persist?

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Annals of Medicine and Surgery

Título del artículo:

Post-COVID 19 neurological syndrome: The need to define a cut-off score between the acute and post-COVID 19 phases

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Annals of Medicine and Surgery

Título del artículo:

Potential distribution of four vectors of American Cutaneous Leishmaniasis: The effect of El Niño and La Niña episodes from the perspective of the ecological niche

The potential distribution of four American Cutaneous Leishmaniasis vectors under average conditions during Neutral (in between episodes), El Niño, and La Niña episodes from 2000 to 2018 were constructed through ecological niche modeling. The potential distribution in El Niño and La Niña were compared with the Neutral distribution. The four vector species (Lutzomyia gomezi, Lutzomyia ovallesi, Lutzomyia panamensis, and Lutzomyia trapidoi) decreased the potential distribution with the occurrence of El Niño and La Niña episodes. During El Niño, the reduction was concentrated over the dry ecosystems, while with the occurrence of La Niña, the potential distribution decreased over most of the Neotropic, leaving areas of climatic suitability concentrated in the Andean and Amazon areas, along with some scattered patches. We found evidence that the occurrence of the climatic anomalies has an effect on the potential distribution of this vector species.

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Acta Tropica

Título del artículo:

Latin-American Ambulatory Blood Pressure Registry (MAPA-LATAM): An urgent need

Hypertension (HT) is one of the main risk factors for cardiovascular disease. Although it is a global problem, independently of economic situation, region, race or culture, the data available on Latin America are limited. Clinical guidelines emphasise the importance of obtaining reliable blood pressure readings. For this reason, the use of ambulatory blood pressure monitoring (ABPM) is recommended. This improves precision and reproducibility, resulting in better diagnosing and therapeutic decision-making, and constitutes a better estimation of prognosis than office measurements. Unfortunately, there is no global prospective ABPM registry for all of Latin America that analyses HT prevalence, the level of knowledge about it, treatment percentage and the degree of control. Consequently, the authors of this article consider its implementation a priority.

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Revista Clinica Espanola

Título del artículo:

The Global Ambulatory Blood Pressure Monitoring (ABPM) in Heart Failure with Preserved Ejection Fraction (HFpEF) Registry. Rationale, design and objectives

Hypertension is a major risk factor for the development of heart failure with preserved ejection fraction (HFPEF) and blood pressure (BP) in itself is an important marker of prognosis. The association of BP levels, and hemodynamic parameters, measured by ambulatory blood pressure monitoring (ABPM), with outcomes, in patients with HFPEF is largely unknown. Patients with HFPEF have a substantial burden of co-morbidities and frailty. In addition there are marked geographic differences in HFPEF around the world. How these difference influence the association between BP and outcomes in HFPEF are unknown. The Global Ambulatory Blood Pressure Monitoring (ABPM) in Heart Failure with Preserved Ejection Fraction (HFpEF) Registry aims to assess the relevance of BP parameters, measured by ABPM, on the outcome of HFPEF patients worldwide. Additionally, the influence of other relevant factors such as frailty and co-morbidities will be assessed. Stable HFPEF patients with a previous hospitalization, will be included. Patients should be clinically and hemodynamically stable for at least 4 weeks before study inclusion. Specific data related to HF, biochemical markers, ECG and echocardiography will be collected. An ABPM and geriatric and frailty evaluation will be performed and the association with morbidity and mortality assessed. Follow up will be at least one year.

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Journal of Human Hypertension

Título del artículo:

An Indoor Physical Activity Area for Increasing Physical Activity in the Early Childhood Education Classroom: An Experience for Enhancing Young Children\'s Movement

Several aspects of the indoor early childhood education (ECE) environment may be associated with physical activity (PA), including indoor areas. Modifying the indoor physical environment in classrooms could have significant potential to influence PA in young children. However, to our knowledge, PA promotion interventions involving changes to the ECE indoor physical environment have not been empirically implemented or monitored by accelerometry and direct observation. Therefore, the aims of this study were twofold: (a) to evaluate personal, social, and environmental correlates of moderate-vigorous PA (MVPA) in young children during indoor free play time; and (b) to assess the impact of incorporating a physical activity area in an indoor ECE environment on PA patterns during recess and the overall school day. Outcomes were measured at baseline, at 1 week post-intervention, and at 6 weeks’ follow-up. We studied contextual variables such as the presence of others, location, availability of equipment, and gender-based group interactions during indoor free play. It is notable that at 1-week post-intervention, both girls and boys increased their PA levels, but by the 6-week follow-up, the increase in MVPA was significantly higher in boys compared to girls, suggesting that our PA area is not benefitting girls to the same extent as their male counterparts. In addition, at all time points, boys spent more time during recess and overall in MVPA minutes than girls. MVPA is below the recommended levels for this age during the school day, the role of the indoor physical environment and context should be revised.

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Early Childhood Education Journal

Título del artículo:

Fecal microbiota transplant in a patient with canine parvovirus: Clinical case report

It is reported the case of a four-month-old puppy that was admitted to the consultation at the veterinary clinic «Vet Center», Bucaramanga, Colombia, due to a severe gastroenteric disturbance. The patient showed signs of depression, vomiting, dehydration, and fever. The haematological evaluation revealed slight anaemia, and the canine parvovirus test was positive. For the stabilization and treatment of the patient, an intravenous catheter was placed for the infusion of intravenous lactated Ringer’s solutions, antibiotics, antiemetics, and vitamins. In addition, a faecal microbiota transplant was performed as additional therapy after 12 hours of hospitalization, repeating at 12 hours, giving satisfactory results that are discussed in this clinical report.

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Revista de Investigaciones Veterinarias del Peru

Título del artículo:

Microbial community dynamics and electricity generation in MFCs inoculated with POME sludges and pure electrogenic culture

Palm Oil Mill Effluent (POME) requires treatment before disposal due to its high organic matter content. In this study, the electrical performance and wastewater treatment efficiency were evaluated for Microbial Fuel Cells (MFC) treating unsterile POME with chemical oxygen demand (COD) from 200 to 10 000 mg/L. Since the inoculum type is a key factor in MFC performance, three types of sludge (methanogenic sludge (MS), facultative sludge (FS), and dry sludge (DS), obtained from the current POME treatment ponds were evaluated as inoculum. Dry sludge (DS) developed a maximum power output of 3.30 W/m3 by oxidizing 71% out of the COD provided by POME (1000 mg/L). Also, raw POME microbiota contributed to an enrichment of the community in DS inoculum along with the operation, in which Geobacter was the predominant genus reaching a current generation of 247 mA/m2 and a power density of 2.36 W/m3. Conversely, pure electrogenic (Shewanella sp.) inoculation led to a diversification process, resulting in a lower current generation of 52 mA/m2 and a power density of 0.10 W/m3. Consequently, microbial community dynamics revealed that MFC inoculation tends to a microbial equilibrium wherein generation of high current density was achieved by gradual microbial enrichment rather than external electrogenic invasion.

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International Journal of Hydrogen Energy

Título del artículo:

Experimental diagnostic and choice of technological parameters of ion nitriding process

Modern hardening coatings, known as duplex coatings, are a combination of two types of surface treatment: preliminary ion nitriding of the substrate and subsequent deposition of a thin hardening film based on ceramic coatings. Nitriding is a process of diffusion saturation of the metal surface with a doping element (nitrogen from the gas phase). The key process parameters are the operating pressure and the temperature of the substrate, which determine the intensity of diffusion fluxes and the efficiency of processing. In this paper, we present a research of the influence of the pressure range (p1 = 1000 Pa, p2 = 400 Pa, and p3 = 200 Pa) in the nitriding process of high-speed steel substrates and the development of a temperature measurement system with ceramic insert made of aluminum nitride that enabled us to control the temperature during the process in the range 470 oC-570 oC. The results show that pressure should not exceed 200 Pa.

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Journal of Physics: Conference Series

Título del artículo:

Study of methodologies for the formation of a layer that inhibits the formation of bacterial strains in cardiac instruments

Implantable cardiovascular electronic devices are now an essential part of clinical practice in cardiology. The presence in a large number of adult population of problems in the electrical conduction system and several indications with multiple comorbidities has led to an increase in use of implantable cardiovascular electronic devices. However, the application benefit of these devices has been affected by the higher incidence of infections, which represent a serious complication that can lead to significant morbidity, mortality and cost for health centers due to antibiotic treatments, device replacement and longer hospitalization times. For this reason, the present analysis is oriented to possibility of reducing the dissemination of Staphylococcus Aureus by evaluating different techniques for adsorption of a vancomycin antibiotic film in implantable cardiovascular electronic devices. Through this analysis it is possible to establish a new alternative prophylactic method to avoid risks to the health of patients who have problems in the electrical conduction system, which are prone to becoming infected by Staphylococcus Aureus strains during the implantation of the device; in this way, infection can be controlled locally without requiring removal of the initial device and thus avoid an intracardiac compromise that leads to major complications such as endocarditis.

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Journal of Physics: Conference Series

Título del artículo:

Characterization of the clinoptilolite zeolite and its potential application as the basis of a filtering system for the oil industry

Zeolites are minerals with a wide application in the field of Petrochemicals, mainly as catalysts, in oil refining processes, but their structure and composition also make them good filter materials, for that reason they are used in oil refining processes. Water treatment, when an oil well is exploited, a large amount of water is obtained from the reservoir, known as production water, which is treated and reused in injection processes in the same reservoir, the water from production, contains a high amount of organic compounds, which in many cases prevent an adequate implementation of treatments in the wells, which is why a removal of these organic molecules must be made, in this research, the synthetic zeolite clinoptilolite-Na is used, as a filtration system for organic compounds, using methylene blue as a reference, with which retentions were obtained up to 90%.

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Journal of Physics: Conference Series

Título del artículo:

Implementation of Tite Liner technique for maintenance and rehabilitation of a Colombian oil pipeline

One of the greatest challenges for petrochemical industry is corrosion prevention, mitigation and control, a phenomenon that generates a high negative impact due to materials degradation and that in recent years has increased as a result of multiphase fluids processing. Thus, there are different mechanisms of damage by internal corrosion that are generated during transport of multiphase fluids with high content of corrosive agents such as carbon dioxide, solid particles and sediments increased because of transport conditions. The technique Tite Liner was used for maintenance and repair of a Colombian oil pipeline with severe integrity problems. Equally, design and tuning of physical and chemical properties of the coating material was carried out, since they remained unchanged during thermofusion welding process, the initial compression for insertion in the system, the subsequent expansion to fit the pipeline internal dimensions and the system start up at high pressure. The experimental analysis displayed an improvement in the operational conditions of the line. This led to a decrease in the operating expenses of the pipeline, directing those assets in the physical recovery of other industrial equipment inherent to the hydrocarbon transportation process.

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Journal of Physics: Conference Series

Título del artículo:

Assessment of an austenitic steel deterioration using a tool for statistical analysis

Predictive statistical models are widely used in research development to represent linear and non–linear trends that occur in natural phenomena, generally associating the effect caused by multiple adjustable parameters on measurable experimental results. One of the greatest benefits of these models is their application in predictive analysis, since this allows to facilitate decision–making at industrial level in short time, and therefore they are widely used in sectors such as petrochemical industry. In this field, predictive statistical models are generated from experimental results for dependent variables such as materials corrosion rate. In these cases, the models are established based on dependent variables such as: chemical composition of corrosive medium; exposure time; system temperature and type of exposed material, among others. For this reason, in present investigation a statistical model was determined for corrosion rate of AISI 316 steel exposed to a Colombian heavy crude oil as a function of system temperature and exposure time. Development of this statistical model allows its industrial implementation as a tool for prediction of AISI 316 steel sulfidic corrosion rate in a transfer line used for heavy crude oil refining in temperature and exposure time ranges commonly present in distillation units.

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Journal of Physics: Conference Series

Título del artículo:

Frailty levels in non-institutionalized older adults and sociodemographic characteristics

Introduction: Frailty in older adults is a public health challenge and a priority, given its effects on the functional decline of individuals. Several factors account for its occurrence, including individual aspects. Purpose: To determine frailty levels and their association with sociodemographic characteristics in non-institutionalized older adults. Method: A crosssectional study was conducted on a sample consisting of 2 374 non-institutionalized adults older than 60 years from the Caribbean region of Colombia. The subjects were selected using probabilistic methods; patients with physical and mental disabilities were excluded. The frailty levels were determined based on the five criteria proposed by Fried. Results: The average age of the subjects was 72.2 ± 7.3 years, and the frailty frequency was 20.2 % among women and 25.1 % among men. Sex and age were found to be associated with frailty levels (p < 0.05). The risk of frailty was lower in women than in men (OR =0.54; CI 95 %=0.41-0.71). Subjects older than 85 years showed a frailty risk 1.95-fold higher than that of the younger subjects. (OR = 1.95; CI 95 %=1.3-2.92). Conclusion: A high frequency of frailty was found in older adults, with a significant percentage of pre-frail subjects. Identifying frailty is essential for decisionmaking and individualization of a treatment since it is closely related to adverse health events.

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Gaceta Medica de Caracas

Título del artículo:

Project-based learning as a teaching strategy in health sciences

Introduction: In teaching-learning processes, professors must continually reflect on the strategies applied directly in the classroom. The effect of methodologies such as problem-based learning, project-based learning, technology-supported simulations, among others, has been studied in comparison with traditional methodologies. Objective: To describe the strengths of project-based learning as an educational strategy in the context of health sciences. Development: The teaching-learning process of health sciences requires dynamic strategies that allow the articulation of the acquired knowledge, with a practical vision of disciplines in a context based on problem solving and critical thinking. Project-based learning is highlighted as a methodology that requires active, investigative and reflective participation to solve a problem; thus, knowledge is the consequence of discussion, argumentation and decision-making, which imply the construction of such a solution. Conclusions: Project-based learning can introduce improvements and changes with respect to traditional strategies, by promoting motivation, collaborative work, as well as knowledge acquisition and consolidation in students. Likewise, it is a methodology based on student self-training and strengthening their capacity for oral and written expression, as well as time planning, thus facilitating the formation and participation in interdisciplinary teams, essential competences for an ideal performance of health professionals.

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Revista Cubana de Educacion Medica Superior

Título del artículo:

Development of an amplicon-based next-generation sequencing protocol to identify leishmania species and other trypanosomatids in leishmaniasis endemic areas

Trypanosomatid infections are an important public health threat affecting many low-income countries across the tropics, particularly in the Americas. Trypanosomatids can infect many vertebrate, invertebrate, and plant species and play an important role as human pathogens. Among these clinically relevant pathogens are species from the genera Leishmania and Trypanosoma. Mixed trypanosomatid infections remain a largely unexplored phenomenon. Herein, we describe the application of an amplicon-based next-generation sequencing (NGS) assay to detect and identify trypanosomatid species in mammalian reservoirs, human patients, and sand fly vectors throughout regions of Leishmania endemicity. Sixty-five samples from different departments of Colombia, including two samples from Venezuela, were analyzed: 49 samples from cutaneous leishmaniasis (CL) patients, 8 from sand flies, 2 from domestic reservoirs (Canis familiaris), and 6 from wild reservoirs (Phyllostomus hastatus). DNA from each sample served to identify the presence of trypanosomatids through conventional PCR using heat shock protein 70 (HSP70) gene as the target. PCR products underwent sequencing by Sanger sequencing and NGS, and trypanosomatid species were identified by using BLASTn against a reference database built from trypanosomatid-derived HSP70 sequences. The alpha and beta diversity indexes of amplicon sequence variants were calculated for each group. The results revealed the presence of mixed infections with more than two Leishmania species in 34% of CL samples analyzed. Trypanosoma cruzi was identified in samples from wild reservoirs, as well as in sand fly vectors. Coinfection events with three different Leishmania species were identified in domestic reservoirs. These findings depose the traditional paradigm of leishmaniasis as being a single-species- driven infection and redraw the choreography of host-pathogen interaction in the context of multiparasitism. Further research is needed to decipher how coinfections may influence disease progression. This knowledge is key to developing an integrated approach for diagnosis and treatment.

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Microbiology Spectrum

Título del artículo:

Phylogenomic analysis and Mycobacterium tuberculosis antibiotic resistance prediction by whole-genome sequencing from clinical isolates of Caldas, Colombia

Mycobacterium tuberculosis (M. tuberculosis) was the pathogen responsible for the highest number of deaths from infectious diseases in the world, before the arrival of the COVID-19 pandemic. Whole genome sequencing (WGS) has contributed to the understanding of genetic diversity, the mechanisms involved in drug resistance and the transmission dynamics of this pathogen. The object of this study is to use WGS for the epidemiological and molecular characterization of M. tuberculosis clinical strains from Chinchiná, Caldas, a small town in Colombia with a high incidence of TB. Sputum samples were obtained during the first semester of 2020 from six patients and cultured in solid Löwenstein-Jensen medium. DNA extraction was obtained from positive culture samples and WGS was performed with the Illumina HiSeq 2500 platform for subsequent bioinformatic analysis. M. tuberculosis isolates were typified as Euro-American lineage 4 with a predominance of the Harlem and LAM sublineages. All samples were proven sensitive to antituberculosis drugs by genomic analysis, although no phenotype antimicrobial tests were performed on the samples, unreported mutations were identified that could require further analysis. The present study provides preliminary data for the construction of a genomic database line and the follow-up of lineages in this region.

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PLoS ONE

Título del artículo:

Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis

Background: In randomised controlled trials, fixed-dose combination treatments (or polypills) have been shown to reduce a composite of cardiovascular disease outcomes in primary prevention. However, whether or not aspirin should be included, effects on specific outcomes, and effects in key subgroups are unknown. Methods: We did an individual participant data meta-analysis of large randomised controlled trials (each with ≥1000 participants and ≥2 years of follow-up) of a fixed-dose combination treatment strategy versus control in a primary cardiovascular disease prevention population. We included trials that evaluated a fixed-dose combination strategy of at least two blood pressure lowering agents plus a statin (with or without aspirin), compared with a control strategy (either placebo or usual care). The primary outcome was time to first occurrence of a composite of cardiovascular death, myocardial infarction, stroke, or arterial revascularisation. Additional outcomes included individual cardiovascular outcomes and death from any cause. Outcomes were also evaluated in groups stratified by the inclusion of aspirin in the fixed-dose treatment strategy, and effect sizes were estimated in prespecified subgroups based on risk factors. Kaplan-Meier survival curves and Cox proportional hazard regression models were used to compare strategies. Findings: Three large randomised trials were included in the analysis (TIPS-3, HOPE-3, and PolyIran), with a total of 18 162 participants. Mean age was 63·0 years (SD 7·1), and 9038 (49·8%) participants were female. Estimated 10-year cardiovascular disease risk for the population was 17·7% (8·7). During a median follow-up of 5 years, the primary outcome occurred in 276 (3·0%) participants in the fixed-dose combination strategy group compared with 445 (4·9%) in the control group (hazard ratio 0·62, 95% CI 0·53–0·73, p<0·0001). Reductions were also observed for the separate components of the primary outcome: myocardial infarction (0·52, 0·38–0·70), revascularisation (0·54, 0·36–0·80), stroke (0·59, 0·45–0·78), and cardiovascular death (0·65, 0·52–0·81). Significant reductions in the primary outcome and its components were observed in the analyses of fixed-dose combination strategies with and without aspirin, with greater reductions for strategies including aspirin. Treatment effects were similar at different lipid and blood pressure levels, and in the presence or absence of diabetes, smoking, or obesity. Gastrointestinal bleeding was uncommon but slightly more frequent in the fixed-dose combination strategy with aspirin group versus control (19 [0·4%] vs 11 [0·2%], p=0·15). The frequencies of haemorrhagic stroke (10 [0·2%] vs 15 [0·3%]), fatal bleeding (two [<0·1%] vs four [0·1%]), and peptic ulcer disease (32 [0·7%] vs 34 [0·8%]) were low and did not differ significantly between groups. Dizziness was more common with fixed-dose combination treatment (1060 [11·7%] vs 834 [9·2%], p<0·0001). Interpretation: Fixed-dose combination treatment strategies substantially reduce cardiovascular disease, myocardial infarction, stroke, revascularisation, and cardiovascular death in primary cardiovascular disease prevention. These benefits are consistent irrespective of cardiometabolic risk factors. Funding: Population Health Research Institute.

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The Lancet

Título del artículo:

Notoedric mange in a domestic cat: Application of ivermectin and supportive therapy

Feline scabies is a disease that is caused by Notoedres cati, a sarcoptic mite that injures the skin tissue. The present clinical case relates a notoedric scabies in a domestic cat, clinical observations, diagnostic test, and treatment. A 4-year-old male neutered domestic short haired cat was brought at a veterinary clinic. Alopecia, erythema, scales, crusts and hyperkeratosis were observed on the head, and pinnae and malodorous from lesions were observed in dermatological examination. Deep skin scrapings were collected. Microscopic examination revealed adult live mites presence. Based on the morphology, the mites isolated were identified as Notoedres cati. Ivermectin oral capsules (300μg/kg), repeat dose at 14 days. Bath with chlorhexidine and Benzoyl peroxide every 5 days for two months were applied. Moreover, multivitamin complexes were supplied daily, orally. An immunostimulant 1mL/10kg. IM, again applied two days. A clinical improvement in the cat was observed after administered this treatment. The present study reports notoedric mange in a domestic short haired cat in Colombia. The application of ivermectin with supportive therapy was useful in the treatment of notoedric scabies in this cat. The application of products other than ivermectin showed positive clinical observations in the recovery of this patient with feline scabies.

Acerca de la revista donde se publicó este artículo:

International Journal of Veterinary Science