Título del artículo:

Evaluation of native microorganisms for biodegradation of oil and grease in palm oil refinery effluents

The use of novel mixed microbial consortia composed of native yeast and bacteria was evaluated for the treatment of palm oil mill effluents (POME) from an oil refining process. For this purpose, 31 native yeast and bacteria isolates demonstrating the ability to remove fats, oils and greases were evaluated, either as single organisms or mixed inocula, for the treatment of POMEs. Molecular and biochemical characterizations revealed that isolates corresponded to Candida, Bacillus and Pseudomonas genera. Seven mixed inocula, containing the 6 most degrading isolates, were established and tested for the removal of palm oil in liquid culture, achieving 68 to 84 % removal after 48 h. The inoculum constituted by all of the isolates produced the best results with an overall COD reduction from 1840 to 260 mg/L (84 %), evidencing a synergic effect of the microorganisms. The use of the same inoculum for the treatment of a palm oil mill effluent led to a removal of 75 % organic matter and 72 % oil and grease after 48 h. Our results demonstrated the ability of these isolates to use palm oil as sole carbon source and effectively decrease the concentration of pollutants in palm oil mill effluents in a short period of time. The use of these microorganisms may provide adaptive advantages that could improve POME remediation processes, especially with mixtures of native bacteria and yeast able to degrade palm oil as sole carbon source.

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Biotecnologia Aplicada

Título del artículo:

Social disparities explain differences in hypertension prevalence, detection and control in Colombia

Objective: Hypertension is the principal risk factor for cardiovascular diseases. The global Prospective Urban Rural Epidemiology study showed that the levels of awareness, treatment and control of this condition are very low worldwide and show large regional variations related to a country\'s income index. The aim of the present analysis was to identify associations between sociodemographic, geographic, anthropometric, behavioral and clinical factors and the awareness, treatment and control of hypertension within Colombia - a high-middle income country which participated in the global Prospective Urban Rural Epidemiology study. Methods and results: The sample comprised 7485 individuals aged 35-70 years (mean age 50.8 years, 64% women). Mean SBP and DBP were 129.12±21.23 and 80.39±11.81 mmHg, respectively. The overall prevalence of hypertension was 37.5% and was substantially higher amongst participants with the lowest educational level, who had a 25% higher prevalence (<0.001). Hypertension awareness, treatment amongst those aware, and control amongst those treated were 51.9, 77.5 and 37.1%, respectively. The prevalence of hypertension was higher amongst those with a higher BMI (<0.001) or larger waist-hip ratio (<0.001). Being male, younger, a rural resident and having a low level of education was associated with significantly lower hypertension awareness, treatment and control. The use of combination therapy was very low (27.5%) and was significantly lower in rural areas and amongst those with a low income. Conclusion: Overall Colombia has a high prevalence of hypertension in combination with very low levels of awareness, treatment and control; however, we found large variations within the country that appear to be associated with sociodemographic disparities.

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Journal of Hypertension

Título del artículo:

The financial burden of family care of the chronically ill in the Colombian Andean region

Objective: To describe and analyze the financial burden of family care of the chronically ill in the Colombian Andean region. Materials and methods: This study is part of the Program for the Reduction of the burden of chronic disease in Colombia. The sample included 92 families residing in the Colombian Andean region. The Instruments “gcpc-un-d” were used to characterize the subjects and the Survey Financial cost of chronic disease care of Montoya et al, to identify the real effective household consumption. The financial burden attributable to family care was determined under the Caracol methodology. Results: Costs that most afflict families of the Colombian Andean Region are in their order health, transportation, housing, food and communications. Family caring for a person with chronic illness affects its effective household consumption. Discussion: Colombian families residing in the Andean region of the country have a high financial burden attributable to caring for a person with chronic disease.

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Revista Ciencias de la Salud

Título del artículo:

Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia

Introduction: Infections with methicillin-resistant S. aureus are a public health problem due to the multi-resistance profile presented by this pathogen. Objective: To determine resistance phenotypes to methicillin, macrolides and lincosamides in S. aureus. Materials and methods: 50 S. aureus strains, isolated from patients of the Hospital Rosario Lopez Pumarejo in the city of Valledupar, were analyzed. Susceptibility tests to methicillin, erythromycin and clindamycin were performed using microdilution and agar diffusion methods. Methicillin resistance was determined through agar dilution technique and inducible clindamycin resistance D-Test. Results: Methicillin resistance reached 50%, five phenotypes were established in the analyzed macrolides and lincosamides: phenotype sensitive to erythromycin and clindamycin (78%); phenotype resistant to erythromycin and clindamycin (16%) with constitutive resistance for both cMLSB antimicrobials, which lead the resistance phenotypes; phenotype with intermediate resistance to both antimicrobials (2%); the intermediate result phenotype resistant to erythromycin and clindamycin (2%); and the RS phenotype resistant to erythromycin and sensitive to clindamycin (2%) that show inducible iMLSB clindamycin resistance with positive D test. Conclusions: The inducible resistance to macrolides, lincosamides and streptogramines is not established through the standard antimicrobial susceptibility test. Not identifying the inducible resistance can lead to clindamycin treatment failure.

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Revista Ciencias de la Salud

Título del artículo:

Technological change in the case of smart textiles: An approach from the dynamic capabilities

Garment making industry belongs to one of the more traditional sectors of the economy, precisely because they are linked to a basic need of human beings: the dress. However, during the last decade is improving the offer of new textile called \"smart\" by their interactions with the environment, since integrated sensors and actuators that allow to detect and respond to different stimuli, becoming increasingly more lightweight, durable and above all: useful. The emergence of this new era of textiles gives rise to countless applications and the possibility for traditional textile and clothing enterprises to explore new markets, supported by the development of dynamic capabilities that enable them maintain sustainable competitive advantages. This work proposes a model under which a set of learning skills coupled with certain capacities of absorption and innovation, can gestate a technological change in the textile making, we must necessarily be supported in another sector as that of technologies of information and communications.

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Espacios

Título del artículo:

Innovation activities in services in small and medium business enterprises in the textile sector of Valledupar, Colombia

The article aims to describe the service\'s activities of innovation in small and medium enterprises (PYMES) in the textile sector in Valledupar, Colombia. The activities include the knowledge\'s acquisition and machines, preparations for innovation, market research and training processes. This research is descriptive, a field research, non-experimental and transactional. The CEO answers a Likert questionnaire. The results indicate the predominant activity is the acquisition of machinery. In contrast, there is a low acquisition of knowledge from abroad and preparation to innovate. The conclusions are the suggestion of innovation\'s plans; market\'s analyses and diversify sources of knowledge.

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Espacios

Título del artículo:

Microbial activity of essential oils of Lippia alba and cymbopogon citratus on streptococcus mutans and cytotoxicity in cho cells

Background: Dental caries is a complex infectious disease of multifactorial origin in which interactions occur between plaque, tooth, biological determinants such as salivary flow, buffering capacity and pH of saliva, predominant organisms, diet and behavioral socioeconomic factors; prevails in the 60-90% of the world’s school-age population. The existing prevention and treatment are not completely effective and generate some side effects, so the search for complementary strategies is necessary for handling. Objetives: To evaluate the capability of essential oils on Lippia alba (Mill). N.E.Br and Cymbopogon citratus (DC.) Stapf to eradicate S. mutans biofilms and its toxicity on eukaryotic cells. Methods: Essential oils were extracted from plant material through steam distillation. Its chemical composition was determined for gas chromatography with mass selective detector (GC-MS). It was used the MBEC-high-throughput technique to determine the removal concentration of S. mutans biofilms. Cytotoxicity was evaluated on CHO cells through The MTT 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium. Results: The major components in both essential oils were Geraniol and Citral. Lippia alba essential oil applied in concentration of 0.01 mg / 100 mL removed 95.8% of S. mutans biofilm and C. citratus essential oil showed a removal activity of 95.4% in the concentrations 0.1, 0.01mg/100 mL and 93.1% in concentration 0.001 mg / 100 mL. None of the essential oils showed toxicity to CHO cells in a 24-hour treatment, with significant differences in relation to the control with methanol (P = 0.00) which inhibits most cells. Conclusions: The L. alba and C. citratus essential oils showed eradication activity against S. mutans biofilms and null cytotoxicity, evidencing a potential use in treating and preventing dental caries.

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Vitae

Título del artículo:

The role of adiponectin in cardiometabolic diseases: Effects of nutritional interventions

Adiponectin is an adipocyte-derived hormone abundantly present in plasma that exerts its effects through the activation of 3 receptors. Its concentrations are negatively regulated by the accumulation of visceral fat, and clinical studies implicate hypoadiponectinemia in the pathogenesis of diabetes mellitus type 2, coronary artery disease, hypertension, and left ventricular hypertrophy. In contrast, high concentrations of adiponectin are associated with a decreased risk of coronary artery disease, with an improvement in the differentiation of preadipocytes into adipocytes, and with increased endothelial nitric oxide production. Therefore, adiponectin appears to be an important molecule involved in limiting the pathogenesis of obesity-linked disorders, and it may have potential benefits in the treatment and prevention of cardiovascular disease. Caloric restriction, moderate alcohol consumption, and consuming a Mediterranean diet increase adiponectin concentrations, and current evidence suggests a positive, dose-dependent relation between ω-3 (n-3) fatty acid intake and circulating concentrations of adiponectin. Recently, it was reported that the administration of aged garlic extract and a single food intervention with pistachios can increase adiponectin concentrations in individuals with metabolic syndrome. Moreover, the Mediterranean diet is associated with higher adiponectin concentrations. Additional studies are needed to evaluate the potential benefits of increasing adiponectin by nutritional interventions in the treatment and prevention of cardiometabolic diseases.

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Journal of Nutrition

Título del artículo:

Hyperglycaemia is associated with worse outcomes in Latin-American individuals with acute myocardial infarction

Background: Alterations in glucose metabolism have been reported as risk and poor prognostic factors for acute myocardial infarction (AMI); however in Latin-American population this information is limited. Thus, an evaluation was performed on the association between glycaemic status and short- and long-term outcomes in patients with a first AMI. Methods: A multicentre, prospective, observational, cohort study was conducted in 8 hospitals from Colombia and Ecuador. Results: A total of 439 patients with confirmed AMI were included, of which 305 (69.5%) had prediabetes or type 2 diabetes mellitus (DM2). Compared with normal glycaemia group, patients with known DM2 had greater risk of prolonged hospital stay (HR: 2.60, 95% CI: 1.38-4.92, P = .003), Killip class iii/. iv (HR: 9.46, 95% CI: 2.20-40.62, P = .002), and in-hospital heart failure (HR: 10.76, 95% CI: 3.37-34.31, P < .001). Patients with prediabetes, new DM2, and known DM2 showed higher rates of major adverse cardiovascular events after 3 years follow-up. Conclusion: Glucose metabolism abnormalities have an important significance in the short- and long-term prognosis in Latin-American patients that survive a first AMI.

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Clinica e Investigacion en Arteriosclerosis

Título del artículo:

Peridomestic Infection as a Determining Factor of Dengue Transmission

Background: The study of endemic dengue transmission is essential for proposing alternatives to impact its burden. The traditional paradigm establishes that transmission starts around cases, but there are few studies that determine the risk. Methods: To assess the association between the peridomestic dengue infection and the exposure to a dengue index case (IC), a cohort was carried out in two Mexican endemic communities. People cohabitating with IC or living within a 50-meter radius (exposed cohort) and subjects of areas with no ICs in a 200-meter radius (unexposed cohort) were included. Results: Exposure was associated with DENV infection in cohabitants (PRa 3.55; 95%CI 2.37–5.31) or neighbors (PRa 1.82; 95%CI 1.29–2.58). Age, location, toilets with no direct water discharge, families with children younger than 5 and the House Index, were associated with infection. Families with older than 13 were associated with a decreased frequency. After a month since the IC fever onset, the infection incidence was not influenced by exposure to an IC or vector density; it was influenced by the local seasonal behavior of dengue and the age. Additionally, we found asymptomatic infections accounted for 60% and a greater age was a protective factor for the presence of symptoms (RR 0.98; 95%CI 0.97–0.99). Conclusion: The evidence suggests that dengue endemic transmission in these locations is initially peridomestic, around an infected subject who may be asymptomatic due to demographic structure and endemicity, and it is influenced by other characteristics of the individual, the neighborhood and the location. Once the transmission chain has been established, dengue spreads in the community probably by the adults who, despite being the group with lower infection frequency, mostly suffer asymptomatic infections and have higher mobility. This scenario complicates the opportunity and the effectiveness of control programs and highlights the need to apply multiple measures for dengue control.

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PLoS Neglected Tropical Diseases

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The environmental profile of a community’s health: A cross-sectional study on tobacco marketing in 16 countries

Objective To examine and compare tobacco marketing in 16 countries while the Framework Convention on Tobacco Control requires parties to implement a comprehensive ban on such marketing. Methods Between 2009 and 2012, a kilometre-long walk was completed by trained investigators in 462 communities across 16 countries to collect data on tobacco marketing. We interviewed community members about their exposure to traditional and non-traditional marketing in the previous six months. To examine differences in marketing between urban and rural communities and between high-, middle- and low-income countries, we used multilevel regression models controlling for potential confounders. Findings Compared with high-income countries, the number of tobacco advertisements observed was 81 times higher in low-income countries (incidence rate ratio, IRR: 80.98; 95% confidence interval, CI: 4.15–1578.42) and the number of tobacco outlets was 2.5 times higher in both low- and lower-middle-income countries (IRR: 2.58; 95% CI: 1.17–5.67 and IRR: 2.52; CI: 1.23–5.17, respectively). Of the 11 842 interviewees, 1184 (10%) reported seeing at least five types of tobacco marketing. Self-reported exposure to at least one type of traditional marketing was 10 times higher in low-income countries than in high-income countries (odds ratio, OR: 9.77; 95% CI: 1.24–76.77). For almost all measures, marketing exposure was significantly lower in the rural communities than in the urban communities. Conclusion Despite global legislation to limit tobacco marketing, it appears ubiquitous. The frequency and type of tobacco marketing varies on the national level by income group and by community type, appearing to be greatest in low-income countries and urban communities.

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Bulletin of the World Health Organization

Título del artículo:

Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: A prospective cohort study

Summary Background Alcohol consumption is proposed to be the third most important modifiable risk factor for death and disability. However, alcohol consumption has been associated with both benefits and harms, and previous studies were mostly done in high-income countries. We investigated associations between alcohol consumption and outcomes in a prospective cohort of countries at different economic levels in five continents. Methods We included information from 12 countries participating in the Prospective Urban Rural Epidemiological (PURE) study, a prospective cohort study of individuals aged 35-70 years. We used Cox proportional hazards regression to study associations with mortality (n=2723), cardiovascular disease (n=2742), myocardial infarction (n=979), stroke (n=817), alcohol-related cancer (n=764), injury (n=824), admission to hospital (n=8786), and for a composite of these outcomes (n=11 963). Findings We included 114 970 adults, of whom 12 904 (11%) were from high-income countries (HICs), 24 408 (21%) were from upper-middle-income countries (UMICs), 48 845 (43%) were from lower-middle-income countries (LMICs), and 28 813 (25%) were from low-income countries (LICs). Median follow-up was 4·3 years (IQR 3·0-6·0). Current drinking was reported by 36 030 (31%) individuals, and was associated with reduced myocardial infarction (hazard ratio [HR] 0·76 [95% CI 0·63-0·93]), but increased alcohol-related cancers (HR 1·51 [1·22-1·89]) and injury (HR 1·29 [1·04-1·61]). High intake was associated with increased mortality (HR 1·31 [1·04-1·66]). Compared with never drinkers, we identified significantly reduced hazards for the composite outcome for current drinkers in HICs and UMICs (HR 0·84 [0·77-0·92]), but not in LMICs and LICs, for which we identified no reductions in this outcome (HR 1·07 [0·95-1·21]; pinteraction<0·0001). Interpretation Current alcohol consumption had differing associations by clinical outcome, and differing associations by income region. However, we identified sufficient commonalities to support global health strategies and national initiatives to reduce harmful alcohol use. Funding Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario, AstraZeneca (Canada), Sanofi-Aventis (France and Canada), Boehringer Ingelheim (Germany and Canada), Servier, GlaxoSmithKline, Novartis, King Pharma, and national or local organisations in participating countries.

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The Lancet

Título del artículo:

Behaviour change strategies for reducing blood pressure-related disease burden: Findings from a global implementation research programme

Background: The Global Alliance for Chronic Diseases comprises the majority of the world\'s public research funding agencies. It is focussed on implementation research to tackle the burden of chronic diseases in low- and middle-income countries and amongst vulnerable populations in high-income countries. In its inaugural research call, 15 projects were funded, focussing on lowering blood pressure-related disease burden. In this study, we describe a reflexive mapping exercise to identify the behaviour change strategies undertaken in each of these projects. Methods: Using the Behaviour Change Wheel framework, each team rated the capability, opportunity and motivation of the various actors who were integral to each project (e.g. community members, non-physician health workers and doctors in projects focussed on service delivery). Teams then mapped the interventions they were implementing and determined the principal policy categories in which those interventions were operating. Guidance was provided on the use of Behaviour Change Wheel to support consistency in responses across teams. Ratings were iteratively discussed and refined at several group meetings. Results: There was marked variation in the perceived capabilities, opportunities and motivation of the various actors who were being targeted for behaviour change strategies. Despite this variation, there was a high degree of synergy in interventions functions with most teams utilising complex interventions involving education, training, enablement, environmental restructuring and persuasion oriented strategies. Similar policy categories were also targeted across teams particularly in the areas of guidelines, communication/marketing and service provision with few teams focussing on fiscal measures, regulation and legislation. Conclusions: The large variation in preparedness to change behaviour amongst the principal actors across these projects suggests that the interventions themselves will be variably taken up, despite the similarity in approaches taken. The findings highlight the importance of contextual factors in driving success and failure of research programmes. Forthcoming outcome and process evaluations from each project will build on this exploratory work and provide a greater understanding of factors that might influence scale-up of intervention strategies.

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Implementation Science

Título del artículo:

Steady state signatures in the time domain for nonintrusive appliance identification

Smart Grid paradigm promotes advanced load monitoring applications to support demand side management and energy savings. Recently, considerable attention has been paid to Non-Intrusive Load Monitoring to estimate the individual operation and power consumption of the residential appliances, from single point electrical measurements. This approach takes advantage of signal processing in order to reduce the hardware effort associated to systems with multiple dedicated sensors. Discriminative characteristics of the appliances, namely load signatures, could be extracted from the transient or steady state electrical signals. In this paper the effect of impact factors that can affect the steady state load signatures under realistic conditions are investigated: the voltage supply distortion, the network impedance and the sampling frequency of the metering equipment. For this purpose, electrical measurements of several residential appliances were acquired and processed to obtain some indices in the time domain. Results include the comparison of distinct scenarios, and the evaluation of the suitability and discrimination capacity of the steady state information.

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Ingenieria e Investigacion

Título del artículo:

Etiology of musculoskeletal injuries in amateur breakdancers

Aim. The aim of this study was to assess the incidence of musculoskeletal injuries in breakdancers and investigate the association with training habits. Methods. Forty-six males and sixteen females completed a questionnaire regarding their training and competition habits (frequency, warm-up and stretching, strength training, protective equipment, move types and supervision) and the musculoskeletal injuries sustained as a result of breakdancing in the previous 12 months. The effects of training habits and sex on injury rates were analyzed by a Mann-Whitney Test and a Kruskal-Wallis Test, while a stepwise linear regression analysis assessed the link between injury rates and quantitative risk factors. Results. The injury rate was 4.02 injuries per 1000 h, with no signiicant difference between males and females (P>0.05). The main injuries affected were the knee (23.4%) and wrist (15.3%), and females were characterized by a signiicantly greater number of inger injuries and a lower number of shoulder injuries that males (P<0.05). In addition, of all the factors evaluated, only the amount of time spent performing breakdance training showed a signiicant association with injury rate (P<0.05). Conclusion. These results suggest that interventions should focus on protecting speciic body parts and improving training quality and recovery.

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Journal of Sports Medicine and Physical Fitness

Título del artículo:

Presence of IgG antibodies against reproductive infections in breeding bulls of Magdalena Medio, Colombia

Background: cattle farming is an important economic activity in several regions of Colombia. However, farmers are unaware of their cattle health status, and particularly of bacterial, parasitic, and viral diseases, which affect reproduction and profitability. Objective: to assess the presence of IgG antibodies against infectious bovine rhinotracheitis (IBR), bovine viral diarrhea (BVD), bovine leukosis, leptospirosis, brucellosis, and Neospora caninum in breeding bulls in the Magdalena Medio of Colombia, according to age, breed, and origin. Methods: a descriptive, cross-sectional study was conducted with 174 male breeding cattle from several subspecies. Animals were above 18 months of age and belonged to dual-purpose farms in the Magdalena Medio region. Presence of IgG anti-IBR, BVD, brucellosis, neosporosis, and leukosis antibodies were determined with an enzyme-linked immunosorbent assay (ELISA). A sample of 156 males was assessed for leptospirosis using a microscopic agglutination test (MAT) in a dark field. Results: IgG anti-IBR antibodies were found in 92.5% of the animals, anti-BVD in 62.6%, anti-Neospora caninum in 79.3%, anti-Brucella abortus in 4.02%, anti-Leptospira pomona in 8.33%, and anti-L. hardjo in 15.38%, with >1:100 titres. Besides, 64.94% prevalence was observed for bovine leukosis. Conclusions: a high prevalence of IgG anti-IBR, IgG anti-BVD, IgG anti-Neospora caninum, IgG anti-leukosis, and IgG anti-lepstospirosis antibodies were observed in Magdalena Medio bulls. With respect to B. abortus, confirmatory and competitive ELISA test should be performed and sanitary standards need to be established. Detection of IgG antibodies among bulls reveals poor sanitary conditions, absent of protective-vaccination antibodies and an urgent need for health control measurements.

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Revista Colombiana de Ciencias Pecuarias

Título del artículo:

Evaluation of agrochemicals and bioinputs for sustainable bean management on the Caribbean coast of Colombia

The sustainable expansion of bean cultivations requires technologies that do not limit their phyto-recovering properties. Therefore, the objective of this study was to propose agronomic management of conservation for bean cultivation considering the microbiological characteristics of two mega-environments of the Colombian Caribbean coast and the compatibility between agrochemicals and bioinputs. The methodology included rhizospheric microbe population counts, identification of phytopathogenic fungi in plant tissues and soils, compatibility studies of pesticides with biocontrollers, and determination of residual contents of pesticides in bean seeds. The microbial populations corresponded to those previously registered for the lower tropics, but with quantitative differences in the genera. Phytophthora, Colletotrichum and Fusarium were registered in the humid Caribbean, while Colletotrichum and Curvularia affectedcrops in the dry Caribbean. The Beauveria bioinput was not compatible with the evaluated agrochemicals, while Trichoderma was compatible with chlorpyrifos, thiabendazole and oxycarboxin. Metarhizium was compatible with glyphosate and oxycarboxin at 10% of the recommended dose. Lindane residues were found in the beans harvested at three of the studied locations. The combined use of agrochemicals and bioinputs on bean crops is feasible as long as the time of application of the latter is made according to the half-life of the chemical and the organic matter content of the soil is increased.

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Agronomia Colombiana

Título del artículo:

Chemosensory disturbances-associated nanocholinergic dysfunction: The case of, not only, myasthenia gravis

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Journal of the Neurological Sciences

Título del artículo:

Multi-wavelength emission through self-induced second-order wave-mixing processes from a Nd³⁺ doped crystalline powder random laser

Random lasers (RLs) based on neodymium ions (Nd3+) doped crystalline powders rely on multiple light scattering to sustain laser oscillation. Although Stokes and anti-Stokes Nd3+ RLs have been demonstrated, the optical gain obtained up to now was possibly not large enough to produce selffrequency conversion. Here we demonstrate self-frequency upconversion from Nd3+ doped YAl3(BO3)4 monocrystals excited at 806 nm, in resonance with the Nd3+ transition 4I9/2 → 4F5/2. Besides the observation of the RL emission at 1062 nm, self-converted second-harmonic at 531 nm, and selfsum-frequency generated emission at 459 nm due to the RL and the excitation laser at 806 nm, are reported. Additionally, second-harmonic of the excitation laser at 403 nm was generated. These results exemplify the first multi-wavelength source of radiation owing to nonlinear optical effect in a Nd3+ doped crystalline powder RL. Contrary to the RLs based on dyes, this multi-wavelength light source can be used in photonic devices due to the large durability of the gain medium.

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Scientific Reports

Título del artículo:

Phosphine-Free Suzuki Cross-Coupling Reaction Using an Efficient and Reusable Pd Catalyst in an Aqueous Medium under Microwave Irradiation

We report here an improved, highly efficient, and general method for the ligand-free Suzuki cross-coupling reaction to the synthesis of biaryls, bipyridyls, thienylpyridine, and allylphenols. Microwave irradiation of (het)aryl halides and (hetaryl, allyl)arylboronic acid N-methyl-iminodiacetic acid (MIDA) ester, using polyurea microencapsulated palladium catalyst (Pd EnCat 30), gave the coupling adducts 1a-x in excellent yields in just 10-18 min.

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Synthetic Communications

Título del artículo:

Zarit burden interview: Psychometric tests for colombia

Objective: This research was designed to determine the validity and reliability of the Zarit Burden Interview, specifically the 22-item Spanish version, as an instrument to measure the burden of care perceived by family caregivers of patients in Colombia with chronic diseases. Materials and Methods: A cross-sectional study of 652 family caregivers of patients with chronic diseases who reside in five regions of Colombia was conducted to establish construct validity, with a factor analysis and internal consistency reliability measured by determining the Cronbach’s alpha value. Result: In terms of construct validity, the study reports the total loading, based on free association of a varimax rotation, and in the dimensions that include interpersonal burden, impact of care, and skills and expectations about care. The factor loadings pertain to the items introduced to measure each of the proposed dimensions. Conclusion: The results showed the 22-item Spanish version of the Zarit Burden Interview is an instrument that can be applied and understood easily in a Colombian population with different educational, socio-economic and cultural levels. It also proved to be valid and reliable for assessing the burden of care perceived by family caregivers of patients with chronic diseases.

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Aquichan

Título del artículo:

Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies

An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania (Viannia) panamensis. A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis-induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm2, 15 min), twice a week for 3 weeks.

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Antimicrobial Agents and Chemotherapy

Título del artículo:

Characterization of disabled people with permanent limitations in mobility and self-care in Giron, Colombia

Objective: To determine the characteristics of people with permanent limitations in mobility and self-care in 17 districts of the urban area of Giron, Santander 2012-2013. Materials and methods: A descriptive, observational, cross-sectional study was conducted using the tool Register for the Location and characterization of the disabled people (RLCDP), designed by the National Administrative Department of Statistics (DANE). Previously trained physiotherapy students interviewed caregivers or disabled people. Results: A total of 189 people were studied of 50.3% women, and 45.5% between 60 and 100 years old. A large majority (79.9%) had alterations in body movement, hands, arms and legs. As regards activities and participation, 91% had difficult to walk, run, jump, and 41.3% found it difficult to lead, move, and use objects with hands. Of the bodily functions, 60.3% involved mobility. General illness diseases were the main cause of disability (33.9%). Conclusions: A high percentage of persons with permanent mobility limitations and caring for themselves in the urban area of Girona are older adults from socioeconomic level 2. The predominant mobility limitations are in the hands, arms, and legs, with involvement in at least two body structures.

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Fisioterapia

Título del artículo:

A semi-decentralized solution for the economic dispatch with transmission losses using a JASON-based multiagent system

Distributed calculation of an economic dispatch can be used for efficient resource allocation in a power distribution system with local generation. The lossless dispatch can be implemented in a fully decentralized way, however, because the impact on real losses in a power distribution systems cannot be neglected, this kind of calculations might lead to suboptimal solutions. This work proposes a semi-decentralized algorithm that solves the economic dispatch with transmission losses. The algorithm was implemented in a multiagent system (MAS) with JASON programming language, using a Contract Net Protocol (CNP) to adjust power output of each generator. CNP algorithm implemented has a good behavior under unconstrained conditions, but further researches are needed to calculate the optimum if capacity constraints are included.

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International Conference on the European Energy Market, EEM

Título del artículo:

Microgrid\'s Energy Management Systems: A survey

Microgrids are a new paradigm for energy distribution systems in which generation (from a local energy source or storage device) is coordinated to supply local energy needs while behaving as a sole system. Benefit maximization in a microgrid is directly related with demand reactiveness and optimal allocation of local energy resources. Because those characteristics can be implemented through an Energy Management System (EMS), knowing the elements that conforms it and how they interact is crucial for the development of microgrids. This paper presents a caracterization of the EMS and some insight about the actual state on this subject. This is done to understand the mechanisms that allow efficient EMS implementations, thus shortening the path towards a power distribution microgeneration with higher short-term/mid-term benefits based on microgrid technology.

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International Conference on the European Energy Market, EEM