Título del artículo:

Evaluation of anti-Candida effect of Co(II) and Cu(II) complexes by variation of coordinating environment. Synthesis and characterization of modifying of 1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol complexes

Pursuing development of metal complexes featuring improved antifungal activity, here we account for the design, synthesis and biological evaluation of triazole-based Co(II) (compounds: 2, 4) and Cu(II) (3, 5) complexes. The characterization of these compounds established that all complexes exhibit stoichiometries of 1:1 between the metal center and multidentade ligand, namely 1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol (1), with complementary chloride (compounds: 2, 3) and acetate (4, 5) ligands. The isolated multidentate ligand (1) and 3–5 were obtained as air-stable solids, while 2 showed significant moisture absorption after 24 h, as determined by infrared spectroscopy. Furthermore, computational calculations for 2 and 3, allows evaluation of the probable geometries. Our results recognize cobalt complexes as significant antifungal molecular species for potential treatment of C. albicans, C. tropicalis, C. parapsilosis, and N. glabrata. These complexes demonstrated greater activity compared to the free ligand, with [Co{1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol-N,N}(CH3COO)2] (4) showing minimum inhibitory concentrations values between 7.81 and 125 μg mL^-1. It is noteworthy that 4 showed no toxicity in mammalian cells and no mutagenic effects, suggesting a favorable safety profile. These results, provides strong basis for the further design and explorative synthesis of novel candidates to tackle biological pathogens by using highly tailorable transition metal complexes.

Acerca de la revista donde se publicó este artículo:

Journal of Molecular Structure