Herramientas de Accesibilidad
Fasciola hepatica is a parasite with a worldwide distribution that affects several mammals, including humans, and is considered a public health problem. Therefore, the aim of this study was to determine the prevalence of Fasciola hepatica in humans, cattle and sheep, as well as to evaluate factors associated with the prevalence. A total of 185 serum samples from sheep, 290 from cattle, and 114 from humans were collected and processed using an in-house developed ELISA to detect IgG antibodies against F. hepatica. Additionally, 185 stool samples from sheep and 290 from cattle were examined using a Dennis sedimentation technique. Risk factors were analyzed using epidemiological surveys. The overall seroprevalence was 46.5% (86/185) in sheep, 32.5% (94/289) in cattle, and no humans tested positive for the infection. The coprological prevalence was 47.7% (86/180) in sheep and 33.7% (98/290) in cattle. Female gender and cattle living with alternate grazing management showed 2.5 and 6.5 times higher probability of infection, respectively. Bovines coexisting with sheep exhibited a higher risk of infection (odds ratio [OR]=4.3) compared to those without sheep. We concluded that F. hepatica in cattle and sheep has an endemic behavior, and therefore represents a problem of public health for rural communities.
Revista Brasileira de Parasitologia Veterinaria
The reading levels of statistical tables achieved by Chilean elementary school students are reported. A questionnaire with items of different levels of reading statistical tables was used to collect the data. The sample was non-probabilistic and consisted of 26 Chilean 8th grade students. A content analysis of the students\' responses was performed, observing that their best performance was in the questions that evaluated the level associated with literal reading of the information in the table. It was also observed that they have problems comparing data from the table or producing new information from it. Although the official curriculum establishes that 8th grade students should be able to interpret statistical tables, the results suggest that they master only its most basic aspects.
Interciencia
Cardiorenal syndrome is a bidirectional pathophysiological alteration with renal or cardiac dysfunction. Its classification and diagnosis are determined by the primary organ and the chronicity of the disease. In the treatment it is important to determine the hemodynamic state and intravascular volume allowing to establish early measures. The objective of this paper is to perform a detailed description of cardiorrenal syndrome allowing understand the importance of timely diagnosis, management, prognosis and evolution. The importance of knowing this disease is the progressive increase in patients with decompensated heart failure who are admitted to the hospital network. A literature search was performed in the PubMed and Scielo databases for updated articles in English or Spanish registered in the last five years on cardiorenal syndrome, its status, diagnosis, therapies and surveillance. Five different types of cardiorenal syndrome have been described according to the organ initially affected and its evolution. In more than 50% of patients hospitalized for decompensated heart failure some degree of renal dysfunction is found. Cardiorenal syndrome is a multifactorial disease with renal, cardiac or bilateral involvement. Follow-up laboratory test (troponins, natriuretic peptides, creatinine) determine the prognosis of each patient.
Medicina Interna de Mexico
Manganese (Mn) is essential for plant growth, as it serves as a cofactor for enzymes involved in photosynthesis, antioxidant synthesis, and defense against pathogens. It also plays a role in nutrient uptake, root growth, and soil microbial communities. However, the availability of Mn in the soil can be limited due to factors like soil pH, redox potential, organic matter content, and mineralogy. The excessive use of chemical fertilizers containing Mn can lead to negative consequences for soil and environmental health, such as soil and water pollution. Recent research highlights the significance of microbial interactions in enhancing Mn uptake in plants, offering a more environmentally friendly approach to address Mn deficiencies. Microbes employ various strategies, including pH reduction, organic acid production, and the promotion of root growth, to increase Mn bioavailability. They also produce siderophores, anti-pathogenic compounds, and form symbiotic relationships with plants, thereby facilitating Mn uptake, transport, and stimulating plant growth, while minimizing negative environmental impacts. This review explores the factors impacting the mobility of Mn in soil and plants, and highlights the problems caused by the scarcity of Mn in the soil and the use of chemical fertilizers, including the consequences. Furthermore, it investigates the potential of different soil microbes in addressing these challenges using environmentally friendly methods. This review suggests that microbial interactions could be a promising strategy for improving Mn uptake in plants, resulting in enhanced agricultural productivity and environmental sustainability. However, further research is needed to fully understand these interactions’ mechanisms and optimize their use in agricultural practices.
Bacteria
Introduction: Tuberculosis is an infectious disease, which in order to understand it from a social context, it is necessary to recognize the realities built by the community in front of it, integrating its knowledge, beliefs and practices with the sociodemographic and economic conditions to understand its appearance and development. Objective: Understand the knowledge, beliefs, practices, socioeconomic conditions and educational aspects of TB patients in the municipality of Pereira (Colombia), 2021, in order to re-educate them about their care. Methodology: Qualitative, descriptive study in users who attend the Tuberculosis Control Program; of which 14 patients who meet the inclusion criteria are selected. A semi-structured interview is carried out with all the participants until information saturation is obtained, through five categories: knowledge, beliefs, practices, socioeconomic conditions and educational aspects related to Tuberculosis, to understand it from the social construction expressed by patients and generate a holistic approach that allows them to re-educate them in their care. Results: 57.1 % are female, average age: 38 years, of mixed ethnicity; 50 % live in free union; 71.4 % live with the family; 28.6 % have primary and secondary education; 71.4 % work; 100 % live in an urban area. The qualitative results yield five categories: knowledge, beliefs, practices, socioeconomic conditions, and educational aspects of TB. Conclusion: There is limiting knowledge regarding the origin and transmission of the disease with beliefs associated with poverty and stigmatization that negatively affects the economic and emotional condition of patients and their support network in the care of the disease.
Salud Uninorte
Background and objective. Nasal fracture is the most common facial injury, accounting for more than 50% of all facial fractures in adults. Because it is often not diagnosed and treated promptly, it can generate different degrees of functional limitation and undesirable aesthetic results. Few studies evaluate the satisfaction of patients treated with the closed nasal fracture reduction technique. Our objective is to evaluate functional and aesthetic satisfaction after closed reduction of a nasal bone fracture in a hospital in Colombia, using the nasal obstruction symptom evaluation (NOSE) and subjective aesthetic scales. Methods. Prospective analytical observational study of patients with nasal fractures undergoing closed reduction at the University Hospital of Santander, Colombia. The scores of the NOSE scales and subjective aesthetics were recorded, before and 2 months after surgery. Results. We evaluated 55 patients, 90.9% men. Median age 31 years (IQR 24-48). The main injury context was physical violence (40%), followed by traffic accident (32.7%). After the procedure, the patients presented improvement in nasal obstruction measured with the NOSE scale (p<0.001); before surgery, 89% had moderate-severe nasal obstruction, later it decreased to 14.5%. The NOSE scale showed reliability due to internal consistency with Cronbach\'s alpha of 0.8317. After surgery, there was an increase in satisfaction regarding the nasal appearance (p<0.001). Conclusions. The NOSE questionnaire allows us to quantify the improvement of nasal obstruction symptoms in patients with closed reduction due to nasal bone fracture. Improvement of nasal obstructive symptoms and increased aesthetic satisfaction was observed.
Cirugia Plastica Ibero-Latinoamericana
Objective: To design a protocol for telerehabilitation of the lower limb amputee patient using mobile technologies. Methods: Quantitative descriptive study. For the design of the protocol, a literature search in indexed databases and validation of the content by experts in the field were carried out. Thirteen experts in the field of rehabilitation were convened to evaluate the content of the protocols in terms of adequacy, pertinence and relevance. Subsequently, a consensus was reached to define the protocols used in the software. A Likert-type scale with a score from 1 to 5 was used, where 1 refers to the lowest rating and 5 corresponds to the highest, scores that were then translated into three categories where 1 and 2 became \"Not important\", 3 and 4 were classified as \"Useful, not essential\", and 5 was classified as \"Essential\", for the calculation of the content validity index. The Fleiss Kappa coefficient was estimated for each criterion, where the scale established by Landis and Koch, which qualitatively expresses the strength of agreement between the evaluators, was taken into account for the interpretation. Results: The protocol has acceptable properties to be used as an intervention tool for lower limb amputee patients, it was provided in a software for cell phones called Apptivate, which was designed through an interprofessional work and contains the number of repetitions and series to be performed for each exercise, with animations, text and descriptive audio.
Revista de salud publica (Bogota, Colombia)
Objective: To relate anthropometric measures and the level of physical activity pre and post implementation of a physical exercise program aimed at school children between 11 and 14 years of age in a public educational institution. Methods: Experimental study, the sample was made up of 282 school children, (211) intervention group and (71) control group. The PAQ-A (Physical Activity Questionnaire for Adolescents) was applied and anthropometric measurements were taken (weight, height, abdominal perimeter, body mass index). The researchers designed and implemented a physical exercise program during physical education classes. Results: At the initial assessment, 28% of the students in the intervention group were classified as active, a proportion that was maintained for the final assessment without significant changes (27.5%); 28.1% of the control group was active at the initial assessment, a proportion that rose to 31.2%, also without significant changes (p>0.05). Regarding the BMI/age indicator, the proportion of students with overweight or obesity decreased from 40.3% in the pre-intervention to 37.6% in the post-intervention. Conclusions: The level of active physical activity predominated in the male gender, without significant differences; likewise, it can be stated that it decreases with age. The physical exercise program did not have significant effects on anthropometric measures of the population under study, and indirectly it was possible to raise awareness among the different actors about the importance of regular practice of physical activity as a protective factor of health.
Revista de salud publica (Bogota, Colombia)
Objective: To describe the body composition, physical fitness and biochemical risk markers before and after implementation of a physical exercise program in adolescents aged 10 to 17 years of a public school. Methodology: Study with an experimental approach, the sample consisted of 276 schoolchildren, (141) intervention group and (135) control group. Informed consent and assent were completed, anthropometric measurements were taken, the Fitnessgram battery tests were carried out, and a physical exercise program was implemented. Results: Post implementation of the physical exercise program, weight gain and waist circumference were reported in girls. Schoolchildren from 10 to 13 showed a decrease in cholesterol and triglycerides. Men performed better in the Fitnessgram battery, aerobic capacity and strength tests. In the Trunk Lift, and Sit and Reach tests, women exhibited greater flexibility. Conclusions: It is important to evaluate the physical condition of schoolchildren, as a strategy for the prevention of chronic non-communicable diseases. In turn, it is recommended that the regular practice of physical activity be promoted in the school and home environment, as a protective factor of health.
Revista de salud publica (Bogota, Colombia)
Introduction: Cardiovascular diseases represent the leading cause of death worldwide, and education interventions are an effective measure to control modifiable risk factors in patients undergoing cardiac rehabilitation; therefore, studying this phenomenon allows expanding the tools to face this situation. Objective: To determine the impact of educational interventions to foster health in patients undergoing cardiac rehabilitation. Materials and methods: A scientific literature review was conducted in the PubMed, SciELO, LILACS, EBSCO, MEDES, CUIDEN, Dialnet, ScienceDirect and CUIDATGE databases, based on the PRISMA statement proposal for systematic reviews, registered in the Prospero database (CRD42023398444). The Jadad scale was used for the methodological assessment, according to the peer approach. Results: The initial search yielded 14,849 publications, with 10 of them meeting the inclusion criteria. The mean age of the sample population was 63 years old, male gender. Telemedicine and education software design were resources to implement the interventions, finding a reduction in hospitalizations for cardiac reasons. Regarding mental health, long-term reductions in anxiety and depression were found. Conclusions: The time until the first cardiovascular hospitalization was 502 (469-535) days in the Intervention Group, against 445 (400-491) days in the Control Group. When evaluating medication adherence, it was evidenced that 94 % of the participants had improvements. Regarding cardiovascular risk stratification, both the intervention (26 %) and the control (6 %) groups shifted to the lower-risk class.
Aquichan
The case of a young adult patient is presented with a history of polycystic ovary and recent infection by COVID 19 that starts with asthenopia and blurred vision along with headache, fundus examination with bilateral papilledema was performed, laboratory and neuroimaging studies without positive findings, also lumbar puncture with elevated opening pressure so idiopathic intracranial hypertension was diagnosed with subsequent post puncture improvement.
Gaceta Medica Boliviana
Phosphorus (P) is one of the most important elements required for crop production. The ideal soil pH for its absorption by plants is about 6.5, but in alkaline and acidic soils, most of the consumed P forms an insoluble complex with calcium, iron, and aluminum elements and its availability for absorption by the plant decreases. The supply of P needed by plants is mainly achieved through chemical fertilizers; however, in addition to the high price of these fertilizers, in the long run, their destructive effects will affect the soil and the environment. The use of cheap and abundant resources such as rock phosphate (RP) can be an alternative strategy for P chemical fertilizers, but the solubilization of P of this source has been a challenge for agricultural researchers. For this, physical and chemical treatments have been used, but the solution that has recently attracted the attention of the researchers is to use the potential of rhizobacteria to solubilize RP and supply P to plants by this method. These microorganisms, via. mechanisms such as proton secretion, organic and mineral acid production, siderophore production, etc., lead to the solubilization of RP, and by releasing its P, they improve the quantitative and qualitative performance of agricultural products. In this review, addressing the potential of rhizosphere microbes (with a focus on rhizobacteria) as an eco-friendly strategy for RP solubilization, along with physical and chemical solutions, has been attempted.
Bacteria
BACKGROUND: Cryptococcosis is the most common cause of fungal meningitis worldwide and has a mortality of about 181,000 cases annually. It affects mainly HIV-positive patients or people with some cellular immune-response compromise. Even though it is an uncommon disease in immunocompetent subjects it may occur in apparently healthy hosts, in whom it must be recognized because the subacute presentation and the late diagnosis can increase morbidity and mortality on this group. CLINICAL CASE: A 67-year-old male patient, apparently immunocompetent, who consulted referring headache, fever and mental status altered. He was diagnosed with meningeal cryptococcosis by microbiological analyses and serum antigens, treated with fluconazole and liposomal amphotericin B and he had an adequate clinical response with no further complications (after finished the treatment) or neurological sequels. CONCLUSIONS: The clinical suspicion of this entity is very important because multiples causes of immunosuppression result in a major predisposition to the disease.
Medicina Interna de Mexico
The avocado is one of the most consumed foods in the world and it is affected by the mite Oligonychus sp., which affects the generation of chlorophyll by the plant, resulting in a decrease in productivity. Given the economic importance of the avocado, a spatial statistical methodology was used to analyze the risk of a pest in its crops. A total of 202 observations of a 1.1 ha avocado farm were used to measure the number of mites per leaf in the area of Barranca, Perú. Predictive geostatistical methods and indicators were applied. A Spherical semivariogram was adjusted to estimate a Univariate Ordinary Kriging, covariates such as vegetation indicators and geomorphometric variables were used to improve the spatial resolution of the covariates and geostatistical simulation was used and linear co-regionalization models were adjusted with which pest predictions were made with co-Kriging. Finally, the predictions were transformed into a risk model using Kriging Indicator. The results obtained show that the mite presents a stationary process in second order with spatial dependence of less than 10 m, in which univariante Ordinary Kriging was the most efficient. Despite the results, the linear co-regionalization models are consistent, but the geostatistical simulation was not enough to improve the predictions. Covariate data should be incorporated at a higher level of detail and small-scale variations should be analyzed. It is suggested to incorporate covariate data with a higher level of detail and analyze small-scale variations.
Revista Facultad Nacional de Agronomia Medellin
The purpose is to analyze management in educational organizations through the integrated input-output methodology of the dynamic model with emerging technologies, in the institutions “Camilo Torres Restrepo, San José and San Isidro”, municipality of Curumaní (Cesar-Colombia). The research was of an analytical type; supported by the qualitative macro-ethnographic approach. According to the epistemological framework, the research is considered phenomenological. The technique used was the in-depth interview, applying the interview script directed to nine (9) key informant teachers of the mentioned institutions. In basic secondary education, the integrated input-output methodology of the dynamic model using emerging technologies does not constitute a teacher’s priority to respond to learning mediated by virtuality during Covid-19. Finally, it is necessary for classroom managers to effectively apply the theoretical-practical elements related to the integrated input-output methodology in order to assertively guide students in their learning process.
Revista Venezolana de Gerencia
Social responsibility has established links with the educational sphere through the social contract to which educational institutions are called. In view of these links, the purpose of this research is to analyze the features of the teaching function from the dimension of social responsibility, with an ethical approach. A documentary-type methodology was used with a systematic review of the literature on the subject. Preliminary findings show that educational social responsibility demands a teacher whose ethical traits point to an exercise committed to: the formation and transmission of civic and ethical values, the promotion of the relationship between school-community and its environment, the promotion of an open educational institution without physical or disciplinary boundaries, motivated by the organization of vulnerable social groups and education for sustainable development. Final reflections point to the dissolution of barriers between the school and the community to achieve a just, diverse and sustainable environment.
Revista Venezolana de Gerencia
The migratory movement of Venezuelans to Colombia has increased significantly in the last decade. The Colombian state has designed different public policies to regularize the situation of migrants in the country. This paper aims to analyze the public policies formulated by the Colombian state and its management for the social integration of migrants. The methodology consisted of the analysis of legal regulations, programs, projects and plans emanating from the Colombian State bodies, as well as their implementation translated into the level of impact that these public policies can generate for the social integration of migrants. The results show that the regulations account for a public policy that guarantees the right to education by solving the barriers to access to the system, presenting mechanisms to ensure permanence and establishing an identification document such as the PPT for graduation. It is concluded that real public policy management, although at a general level it presents failures in its implementation, these are not the exclusive responsibility of the Colombian state; there are other factors that influence the consolidation of real politics.
Revista Venezolana de Gerencia
Patients with chronic kidney disease (CKD) carry a high cardiovascular (CV) risk. Since whether this risk is reduced by aspirin is unclear, we examined if the effect of aspirin on cardiovascular outcomes varied by baseline kidney function in a primary cardiovascular disease prevention trial. The International Polycap Study-3 (TIPS-3) trial had randomized people without previous cardiovascular disease to aspirin (75 mg daily) or placebo. We now examined aspirin versus placebo on cardiovascular events in participants grouped by estimated glomerular filtration rate (eGFR), using a threshold of 60 ml/min/1.73 m2, and by using tertiles of eGFR. The primary outcome was a composite of non-fatal myocardial infarction, non-fatal stroke or cardiovascular death. A total of 5712 participants were randomized with a mean follow-up of 4.6 years. Of these, 983 (17.2%) had an eGFR under 60 ml/min/1.73 m2 (mean eGFR 49 ml/min/1.73 m2) and 4,729 over 60 ml/min/1.73 m2 (mean 84 ml/min/1.73 m2). In participants with an eGFR under 60 ml/min/1.73 m2 there were 26 primary outcomes in 502 participants on aspirin and 39/481 on placebo (hazard ratio 0.57; 95% confidence interval 0.34-0.94). In participants with an eGFR over 60 ml/min/1.73 m2 there were 90 primary outcomes in 2357 participants on aspirin and 95/2372 on placebo (0.95; 0.71-1.27). With tertiles of eGFR under 70, 70-90, and over 90 ml/min/1.73 m2, risk reductions with aspirin for the primary outcome were larger at lower eGFR levels (0.62; 0.43-0.91) for the lowest tertile, (0.96; 0.62-1.49) for the middle, and (1.30; 0.77-2.18) for the highest tertile. Thus, our findings support aspirin may reduce cardiovascular events in people with moderate to advanced stage CKD.
Kidney International
Objective: To assess state-trait anxiety levels and their correlation with occupational stress and socio-biographical and occupational factors in nursing professionals. Materials and Methods: This is a quantitative, cross-sectional, analytical study conducted in the inpatient units of a university hospital in southern Brazil, with the participation of 162 nursing professionals. For data collection, so-cio-biographical and occupational forms, the Stress-Symptom Scale, the Workplace Stress Scale, and the State-Trait Anxiety Inven-tory were used. The data were analyzed based on descriptive and inferential statistics. Results: Nursing professionals have moderate levels of state-trait anxiety. There is a positive correlation between state-trait anxiety scores, stress scores, and stress dimensions (rho = 0.811, p < 0.001). “Trait” anxiety is associated with years of experience in nursing (PR 0.97) and psychic-mental health follow-up (PR 1.97). “State” anxiety is associated with sex (PR 0.54), education (PR 2.26), and hours of sleep (PR 0.92). Conclusions: “State” anxiety is associated with sex, age, higher education level, and psychic-mental health follow-up; however, years of experience in nursing and hours of sleep were found to be protective factors.
Aquichan
Organizational culture has become a significant element in different organizations of any kind, in this case framed in the linkage that is presented with the nursing program at the University of Santander Cúcuta; because within the trends and managerial innovations arises the need to handle the different concepts and theories that currently make mention of organizational culture to provide nursing professionals with tools and of course components that allow them a better education, training and professional performance. Reason that converges in the following general objective: To analyze the Pedagogical Mediator on the Organizational Culture for the Assertiveness and Empowerment of Knowledge in the Academic Community of the Nursing Program of the University of Santander Campus Cúcuta. The methodology used was framed in mixed approaches (quantitative and qualitative), where a documentary analysis and a description of the variables were worked, plus the appreciations of the key informants, which led to assume a set of knowledge referred to the pedagogical mediator with hypertextual and hypermedial strategies, which allowed dynamizing the academic processes, optimizing time, resources and strengthening the organizational culture to achieve the assertiveness and empowerment of knowledge in the community; which left structured the different ontological components.
Aibi, Revista de Investigacion Administracion e Ingenierias
Objective: to evaluate the performance statistics of average flow (Qave), voiding time (Vtime), and time to maximum flow (TQmax), in addition to maximum flow (Qmax), for diagnosis of infravesical obstruction. Methods: we reviewed urodynamic studies performed in men > 40 years. Obstruction was considered a grade 3-6 in the Schäfer nomogram. Sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-), and the receiver operator characteristic (ROC) curve were calculated for the different components of free uroflowmetry. Results: we analyzed 432 studies. Patients with obstruction had lower values of Qmax and Qave, and higher values of Vtime and TQmax. Considering different thresholds, Qmax had sensitivity, specificity, LR + and LR-values of 12-83%, 50-97%, 1.7-4.46 and 0.32-0.9, respectively; Qave had sensitivity, specificity, LR + and LR-values of 65-95%, 21-66%, 1.22-1.94 and 0.19-0.53, respectively; Vtime had sensitivity, specificity, LR + and LR-values of 49-85%, 26-67%, 1.15-1.54, and 0.57-0.74, respectively; TQmax had a sensitivity, specificity, LR + and LR-of 36-81%, 22-72%, 1.04-1.33 and 0.85-0.87, respectively. The areas under the ROC curves for Qmax, Qave, Vtime and TQmax were 0.75 (95% CI = 0.71-0.79, p < 0.001), 0.71 (95% CI = 0.66-0.75, p < 0.001), 0.62 (95% CI = 0.57-0.67, p < 0.001) and 0.55 (95% CI = 0.5-0.6, p = 0.03), respectively. Conclusions: Qave, Vtime, and TQmax showed a statistically significant discriminatory capacity to predict infravesical obstruction, and therefore they have clinical value as a complement to the information provided by Qmax.
Urologia Colombiana
CEUR Workshop Proceedings
Introduction: Zika virus is transmitted by the bite of infected mosquitoes, but can also occur through intrauterine infection before delivery, and the virus passes to the fetus. Objective: to describe the level of impairment in performance skills and maturational age of children in the Courageous of the Future program with neonatal Zika virus infection. Materials and Methods: the research is framed with a quantitative approach of correlational type supported with a field research and non-experimental design, with a sample of 15 infants of 3, 4 and 5 years old. The collection technique used was the Abbreviated Scale. Results: Regarding the areas evaluated with respect to the maturational age, it was found that the weighting of motor skills and praxis found a correlation coefficient of 0,601 (moderate) and in the sample of the execution skills of 3-year-old children with gestational Zika, a correlation of 0,853 (strong) was obtained. Discussion: Zika virus infection in children, acquired during gestation, strongly limits the performance skills characteristic of the maturational age in this population. Conclusions: there is correlation between infants with gestational zika and the strong affectation in the actions or behaviors that a patient has to move and interact physically with activities, objects and therefore perform a learned motor activity.
Salud, Ciencia y Tecnologia - Serie de Conferencias
The digital divide remains a significant challenge for many communi-ties worldwide. However, recent advancements in AI technology offer a unique opportunity to address this divide by enhancing digital literacy, promoting access to information and resources, and facilitating personalized learning experiences. This chapter explores how machine learning algorithms, natural language processing, and other AI-driven technologies can be leveraged to provide more effective and efficient training tailored to individualneeds and learning styles. Additionally, AI tools can provide more accessible and relevant information to individuals regardless of their level of digital competence. By utilizing AI tools to improve digital literacy, promote access to information and resources, and facilitate personalized learning experiences, we can create a dynamic feedback loop that contributes to closing the digital divide. This chapterproposes that this feedback loop can lead to a cycle of empowerment, where the accumulation of knowledge and resources reinforces the ability to learn and acquire more resources. Finally, this chapter provides recommendations on how to effectively and responsibly use AI tools to address the digital divide.
Understanding Complex Systems
Introduction. Monoclonal B-cell lymphocytosis generally precedes chronic lymphocytic leukemia, affecting about 12% of the healthy adult population. This frequency increases in relatives of patients with chronic B-cell lymphoproliferative disorders. Objective. To determine the frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic B-cell lymphoproliferative disorders, their immunophenotypic/cytogenetic characteristics, a possible relationship with infectious agents, and short-term follow-up in the Colombian population. Materials and methods. Fifty healthy adults with a family history of chronic B-cell lymphoproliferative disorders were studied using multiparametric flow cytometry, cytogenetic/serological testing, lifestyle survey, and 2-year follow-up. Results. The frequency of monoclonal B-cell lymphocytosis found was 8%, with a predominance of female gender and advanced age, increasing to 12.5% for individuals with a family history of chronic lymphocytic leukemia. Three out of four individuals presented chronic lymphocytic leukemia-type immunophenotype, all with low counts. In turn, a significantly higher number of cells/μl is observed in these individuals in T lymphocyte subpopulations, together with a greater predisposition to the disease. The described clonal opulations increase over time in a non-significant manner. Conclusions. The frequency and behavior of monoclonal B-cell lymphocytosis in patients with family history of chronic B-cell lymphoproliferative disorders are like those found in related studies, which suggests that there is no involvement of more relevant genes that can trigger uncontrolled clonal proliferation, but that generates immunological deregulation that could justify a greater risk of serious infection in these individuals.
Biomedica
Universidad de Santander UDES. Vigilada Mineducación.
Resolución otorgada por el Ministerio de Educación Nacional: No. 6216 del 22 de diciembre de 2005 / Personería Jurídica 810 de 12/03/96.
Institución sujeta a inspección y vigilancia por el Ministerio de Educación Nacional. Resolución 12220 de 2016.
Notificaciones administrativas y judiciales:
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