Herramientas de Accesibilidad
Most patients with adult-onset Still\'s disease (AOSD) present with an evanescent, salmon-colored exanthema that is more prominent during febrile peaks and is considered a major diagnostic criterion. However, over the past two decades, an increasing number of atypical cutaneous findings have been reported. Herein, we present a case of AOSD with atypical skin lesions in a Colombian woman and a review of similar cases in Latin American patients. A 21-year-old female was hospitalized for a 3-month history of intermittent fever, joint pain, and pruritic, erythematous rash. On admission, she exhibited polymorphous macules and papules (linear, urticarial) and lichenoid plaques accompanied by eyelid edema, all of which persisted after febrile peaks subsided. The patient fulfilled Yamaguchi\'s criteria for AOSD. A skin biopsy reported multiple apoptotic keratinocytes within the epidermis and a dermal perivascular inflammatory infiltrate. This histopathological pattern has been consistently associated with persistent pruritic eruptions (PPEs), which are characteristic of AOSD with atypical skin lesions. We searched six databases for AOSD cases with atypical cutaneous findings in Latin American patients. Altogether, there were 17 patients (76% female), of whom 14 underwent a skin biopsy: 42% of skin specimens exhibited distinct epidermal alterations compatible with PPEs, while the remaining 58% corresponded to urticaria, dermographism, or classic Still\'s disease rash. Our literature review showed that in Latin American patients with AOSD, atypical skin lesions can correspond to true PPEs but primarily to alternative diagnoses. A skin biopsy is a valuable tool for establishing a prompt diagnosis.
Revista Colombiana De Reumatologia
Introdction: Dyspnea and other exertional symptoms are cornerstone elements in clinical practice, essential for diagnostic processes, risk stratification, and the effective management of respiratory diseases. Objectives: To investigate the intensity of dyspnea and leg discomfort during physical exercise and their relationships with multi-organ functional variables. Methods: A multicenter study involving 948 adult patients evaluated via integrated cardiopulmonary exercise testing (CPET). Results: Dyspnea at peak exercise showed a mean value of 6.1±3.1 and a median of 7 (IQR, 5). Leg discomfort presented a mean value of 6.3±3.1 and a median of 7 (IQR, 5). Symptoms of dyspnea and leg discomfort reached maximal intensity (i.e., 10 points) in 23% and 30% of patients, respectively, while the remaining participants exhibited submaximal symptom levels. Four phenotypes were identified at peak exercise: paucisymptomatic, peripheral, mixed, and dyspneic. These phenotypes were associated with a sequential and progressive impairment of peak work rate (W
Rehabilitacion
Revista Colombiana De Cardiologia
Endocrinologia Diabetes Y Nutricion
Reumatologia Clinica
Accurate prediction of performance degradation in proton exchange membrane fuel cells (PEMFCs) is essential for predictive maintenance and commercial viability. This task is challenged by data scarcity, complex operational noise, and highly dynamic conditions. Current data-driven models often require large datasets and lack adaptive optimization, compromising accuracy or efficiency. To overcome this, we propose a novel self-intelligent gradient descent search mechanism-driven grey neural network (SiGDSM-GNN). The model integrates grey system theory, adept at handling uncertain, limited data, with the nonlinear learning power of neural networks. Its key innovation is a self-intelligent mechanism that dynamically selects and adapts gradient descent strategies during training, significantly enhancing convergence and robustness. Extensive testing on three realistic PEMFC datasets—steady-state, dynamic loading with 5 kHz current ripples, and real-world vehicle operation—demonstrated superior performance. SiGDSM-GNN achieved a mean absolute percentage error of 0.11%, a noise-to-signal ratio of 0.005, and a prediction time of 0.005 s, outperforming benchmark models including optimization algorithms and deep learning hybrids. This work provides a highly accurate, data-efficient, and real-time capable framework for PEMFC degradation forecasting, advancing predictive maintenance strategies for cleaner energy systems.
Journal of Power Sources
Siderophores, high-affinity iron-binding molecules produced by microorganisms, play a crucial role in plant nutrition by facilitating the uptake of iron and other essential nutrients. Several studies have shown that microbial siderophore production enhances iron solubilization, thereby promoting plant growth and resilience under adverse conditions. Other microorganisms, such as endophytic bacteria, have also been proven effective in mobilizing nutrients within plants. Research has identified microbial strains efficient in siderophore production and explored their application in sustainable agricultural systems. However, large-scale production and application pose challenges, including siderophore stability across diverse soil conditions and formulation costs. Future studies should focus on optimizing microbial strains, developing effective formulations, and evaluating environmental impacts. Integrating siderophores into sustainable agricultural practices can reduce the dependency on chemical fertilizers, thereby improving soil health and crop productivity.
Microbial Siderophores for Agricultural Productivity Perspectives of Use in Agriculture
The emergence of multidrug-resistant ESKAPE pathogens underscores the urgent need for sustainable and effective disinfectant solutions. This study reports the green synthesis of silver nanoparticles (AgNPs) using an aqueous leaf extract of Moringa oleifera, with emphasis on the eco-friendly nature and biocompatibility of the resulting nanomaterials. Seven distinct AgNP formulations were obtained by systematically varying synthesis parameters — including temperature and Ag
Microbial Pathogenesis
Background: Most population studies examining heart failure (HF) have been conducted in Western high-income countries (HICs), with limited comparable data from lower-income settings. Objectives: The aims of this study were to describe differences in HF incidence and 30-day, 1-year, and 5-year case fatality rates among HF patients from countries at different income levels and in different global regions and to examine the impact of common and potentially modifiable risk factors for incident HF. Methods: This analysis of the PURE (Prospective Urban Rural Epidemiology) study included 172,653 individuals from 25 HICs, upper middle-income countries (UMICs), lower middle-income countries (LMICs), and low-income countries (LICs) and 8 geographic regions of the world, followed for a median of 15 years. Age- and sex-standardized HF incidence, as well as 30-day, 1-year, and 5-year HF case fatality, were compared by income group and by geographic region. The population attributable fractions (PAFs) for incident HF related to 13 cardiometabolic, lifestyle, socioeconomic, environmental, and psychosocial risk factors were also estimated. Results: The standardized rate of incident HF was 0.39 (95% CI: 0.36-0.41) per 1,000 person-years overall; the rate was highest in UMICs (0.58; 95% CI: 0.52-0.64), followed by HICs (0.36; 95% CI: 0.30-0.43), then LMICs (0.34; 95% CI: 0.30-0.38), and then LICs (0.26; 95% CI: 0.22-0.30). Among regions, the highest HF incidence was in sub-Saharan Africa (1.18; 95% CI: 0.95- 1.41) and Europe and Central Asia (0.86; 95% CI: 0.72-1.00) and lowest in South Asia (0.19; 95% CI: 0.15-0.22). Thirty-day case fatality was highest in LICs (59%) and lowest in HICs (11%); it was highest in South Asia (63%) and sub-Saharan Africa (63%) and lowest in North America (12%). Five-year case fatality after HF diagnosis was highest in LICs (77%) and lowest in HICs (28%); it was highest in South Asia (81%) and sub-Saharan Africa (75%) and lowest in North America (25%). More than 71% of the PAF for HF was attributable to the 13 modifiable risk factors studied, the largest being hypertension (PAF = 25%). Conclusions: HF incidence and associated mortality vary substantially across countries at different levels of economic development and by geographic region. Hypertension is the largest population-level risk factor for HF globally. Preventive measures, early diagnosis, and access to guideline-directed medical therapy should be prioritized to reduce global disparities in HF incidence and mortality.
Journal of the American College of Cardiology
Gastroenterologia Y Hepatologia
Atencion Primaria
Introduction: Bactibilia frequently complicates biliary obstruction, especially in malignant cases with drainage, and is associated with antimicrobial resistance, thereby posing significant therapeutic challenges. This study characterized the microbiological and clinical profiles, antibiotic resistance patterns, and associated risk factors in patients undergoing hepatobiliary surgery in Colombia. Materials and Methods: We conducted a cross-sectional analytical study on 95 patients with positive bacterial cultures following surgery. The analysis included clinical and microbiological variables. For analytical purposes, patients were stratified into two groups: those with PBD and those without, allowing for the assessment of clinical and microbiological differences between the cohorts. We used chi-square tests, Student\'s t-tests, Mann-Whitney tests, and logistic regression. Results: Of the 95 patients, 61.05% were men, with a median age of 67 years. Preoperative exposure to endoscopic retrograde cholangiopancreatography was significantly higher in patients with biliary pancreatitis (73.47%; p=0.001). Escherichia coli exhibited high resistance to ampicillin/sulbactam (74.29%) and ciprofloxacin (59.46%), while piperacillin/tazobactam (89.74%). Resistance to meropenem was notably associated with female sex (odds ratio [OR: 9.55; 95% confidence interval [CI], 1.12-80.9; P=0.038) and longer ICU stay (OR: 1.12; 95% CI, 1.00-1.24; P=0.038). Discussion: This study reveals significant antibiotic resistance in E. coli and K. pneumoniae, especially in patients with preoperative biliary drainage. These findings highlight the importance of tailoring antibiotic prophylaxis based on preoperative cultures to effectively address antibiotic resistance in hepatobiliary surgery.
Infectio
The therapeutic landscape for relapsed or refractory multiple myeloma (RRMM) has evolved with the introduction of B-cell maturation antigen (BCMA)-directed agents and novel triplet combinations; however, robust comparative evidence in lenalidomide-refractory patients with early relapse remains limited. We conducted a systematic review and network meta-analysis (NMA) of phase 3 randomized controlled trials (RCTs) comparing BCMA-targeted therapies with standard regimens in adults with RRMM after 1-3 prior lines. MEDLINE, Embase, CENTRAL, and Web of Science were searched from inception through December 2025. The primary endpoint was progression-free survival (PFS), which was quantitatively synthesized using NMA; overall survival (OS), minimal residual disease (MRD) negativity, and grade ≥3 adverse events were summarized descriptively. Ten phase 3 RCTs met the inclusion criteria. Experimental regimens consistently improved PFS compared with control arms, with hazard ratios ranging from 0.31 to 0.70 across trials. Within the connected network, anti-CD38-based triplets demonstrated the most favorable PFS estimates. Although BCMA-directed therapies showed superior efficacy in direct comparisons, including deeper responses and higher MRD negativity rates, limited network connectivity precluded robust indirect comparisons across therapeutic classes. OS data were heterogeneous and frequently immature, and safety outcomes were not quantitatively synthesized. Multiple therapeutic strategies improve PFS in lenalidomide-refractory RRMM during early relapse. Anti-CD38-based triplets remain a cornerstone of care, while BCMA-directed therapies represent a promising alternative. However, structural limitations of the evidence network warrant cautious interpretation.
Journal of Applied Hematology
Background: Taxes on sugar-sweetened beverages can improve public health. We aimed to characterise the extent and types of sugar-sweetened beverage taxes implemented worldwide and the national characteristics predicting implementation, such as sugar-sweetened beverage intake amounts, disease rates, or economic development. Methods: This longitudinal analysis aggregated serial global datasets (including the Global Dietary Database, Non-Communicable Diseases Risk Factor Collaboration, Global Burden of Disease study, and World Bank data) from 1990 to 2024 in 183 countries to assess sugar-sweetened beverage tax characteristics and national predictors of policy adoption. Sugar-sweetened beverage taxes for public health purposes were identified and characterised, including amounts, fiscal instruments, structures, and covered beverages. Sugar-sweetened beverage consumption, obesity and diabetes prevalence, gross domestic product (GDP), and sociodemographic index (SDI) were assessed as predictors of tax implementation using Cox proportional hazards models with time-varying covariates. Findings: From 1990 to 2024, 64 countries implemented sugar-sweetened beverage taxes, accelerating over time and covering 3·5 billion people globally. South Asia led in adoption (50% of countries; median tax rate 7·5%), followed by southeast and east Asia (47·8%; 5·0%), the Middle East and North Africa (30·0%; 17·0%), and Latin America and the Caribbean (31·3%; 7·0%). Taxes were ad valorem (ie, based on price; 45%), volume-based (44%), sugar-content-based (5%), or mixed (6%), and 13% of countries earmarked revenue for public health. Multivariable-adjusted predictors of tax implementation included diabetes prevalence (hazard ratio [HR]=1·22 [95% CI 1·05–1·43]), obesity prevalence (1·14 [1·00–1·29]), GDP per capita (HR per $10 000: 1·19 [1·06–1·34]), and SDI (0·70 [0·57–0·86]), but not sugar-sweetened beverage intake (0·77 [0·42–1·39]). Interpretation: Global adoption of sugar-sweetened beverage taxes has rapidly accelerated since 1990; however, there is important heterogeneity by region and tax structure, and the taxes are shaped by a country\'s economic capacity, social development, and health conditions. Funding: This work was supported by the National Institutes of Health (R01HL115189).
Lancet Global Health
Introduction: Research into the ontogeny of sporangia and sporogenesis of leptosporangiate ferns is scarce in the scientific literature. Objectives: To describe and analyze the ontogeny of sporangia, sporogenesis, micromorphology, and ultrastructure of mature spores of the fern Anemia hirsuta. Methods: Fertile fronds of A. hirsuta were processed according to standard protocols for sectioning and embedding samples in paraffin and resin. Sections in paraffin were stained with safranin-alcian blue, Toluidine Blue, and PAS/amidoblack. Sections in resin were stained with Toluidine Blue. The samples were prepared for observation under scanning electron microscopy (SEM) to yield detailed descriptions. Mature spores were analyzed by X-ray energy dispersion (XEDS). Ultrathin sections were obtained for transmission electron microscopy (TEM) observation. Results: The entire leptosporangium is formed from a basal and an apical cell derived from a single epidermal cell of the fertile pinna. The mature leptosporangia are globose, with a subapical ring and a short pedicel. During development, the tapetum is initially cellular, and then becomes plasmodial. The sporocytes undergo simultaneous meiotic division to form tetrads of spores in a tetrahedral arrangement. The exospore is formed first, with two layers, a very thin internal layer and a thick outer layer, followed by the endospore, and finally the perispore. The spores are trilete and muriform, with simple or branched siliceous microspines. The perispore associated with the muri and grooves appears to be highly organized with evident ultrastructural differences. Conclusions: The ontogeny of the sporangia and sporogenesis of A. hirsuta is similar to that previously described for leptosporangiate ferns and recorded in some related fossil species. The highly structured and organized perispore is observed. A high silica content in the microspines of the sporodermis is herein reported for the first time in this group.
Revista De Biologia Tropical
Enfermedades Infecciosas Y Microbiologia Clinica
— Background research shows a positive correlation between the Circular Economy and Operational Profitability; however, current interest demonstrates the impact of the Circular Economy on the development of business models. To this end, a documentary analysis was conducted for the period between 2020 and 2025 to investigate this impact, allowing inferences to be drawn about the various changes occurring in Social Accounting, specifically regarding the Circular Economy, business models, and regulatory advancements, including International Financial Reporting Standards (IFRS). The findings confirm that companies investing in the Circular Economy demonstrate greater profitability and production efficiency, despite adverse factors such as: lack of awareness regarding its applicability, investment costs, financing, and the omission of these from reports and non-monetary results in Financial Statements through sections in IFRS. Therefore, progress in revealing this trend is slow in Latin America, especially regarding the structure of models, which remain linear rather than circular. This contrasts with the global average, where the adoption of circular models has generated significant results, such as a reduction in landfill waste through recycling, reuse, and product repair. This translates into greater profitability and improved business competitiveness for those who have implemented these practices. Finally, work must continue on developing a comprehensive accounting model that incorporates the aforementioned findings.
Aibi Revista De Investigacion Administracion E Ingenierias
Revista Argentina De Cardiologia
Revista Argentina De Cardiologia
The objective was to evaluate the performance, carcass and meat quality of 40 lambs classified by RFI (residual feed intake) and RIG (residual intake and gain). Dry matter intake (DMI) was recorded to calculate the RFI and RIG, classified as efficient, moderately or inefficient. After the confinement period, they were slaughtered and the carcass and meat quality were determined. The efficient animals had DMI scores of 0.700 RFI and 0.400 kg/d RIG, lower than the inefficient ones with similar weight gain. The RFI efficient animals showed greater shear force, without effect in the RIG classification. In general, the variables analyzed were not influenced by RFI or RIG. Efficiency measures do not affect the carcass and meat quality of sheep, but they do have the advantage of identifying animals with lower feed consumption, making the system more efficient. However, as the dataset is limited to fully assess the effects, this manuscript can be used as preliminary results for future studies.
Meat Science
Theta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training phase of some learning paradigms, suggesting that it may be implicated in hippocampus-dependent long-term memory processing. Object recognition memory (ORM) allows animals to identify familiar items and is essential for remembering facts and events. In rodents, long-term ORM formation requires a functional hippocampus but the involvement of the MS in this process remains controversial. We found that training adult male Wistar rats in a long-term ORM-inducing learning task involving exposure to two different, but behaviorally equivalent novel stimuli objects increased hippocampal theta power, and that suppressing theta via optogenetic MS inactivation caused amnesia. Importantly, the amnesia was specific to the object the animals were exploring when the MS was inactivated. Taken together, our results indicate that the MS is necessary for long-term ORM formation and suggest that hippocampal theta activity is causally linked to this process.
Molecular Brain
Context: Low cognitive scores are risk factors for cardiovascular outcomes. Whether this relationship is stronger using novel cognitive indices is unknown. Methods: Participants in the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial who completed both the Montreal Cognitive Assessment (MoCA) score and Digit Substitution Test (DSST) at baseline (N = 8772) were included. These scores were used to identify participants with baseline substantive cognitive impairment (SCI), defined as a baseline score on either the MoCA or DSST ≥ 1.5 SD below either score\'s country-specific mean, or SCI-GM, which was based on a composite index of both scores calculated as their geometric mean (GM), and defined as a score that was ≥ 1.5 SD below their country\'s average GM. Relationships between these measures and incident major adverse cardiovascular events (MACE), and either stroke or death were analyzed. Results: Compared with 7867 (89.7%) unaffected participants, the 905 (10.3%) participants with baseline SCI had a higher incidence of MACE (unadjusted hazard ratio [HR] 1.34; 95% CI 1.11, 1.62; P = 0.003), and stroke or death (unadjusted HR 1.60; 95% CI 1.33, 1.91; P < 0.001). Stronger relationships were noted for SCI-GM and MACE (unadjusted HR 1.61; 95% CI 1.28, 2.01; P < 0.001), and stroke or death (unadjusted HR 1.85; 95% CI 1.50, 2.30; P < 0.001). For SCI-GM but not SCI, all these relationships remained significant in models that adjusted for up to 10 SCI risk factors. Conclusion: Country-standardized SCI-GM was a strong independent predictor of cardiovascular events in people with type 2 diabetes in the REWIND trial.
Journal of Clinical Endocrinology and Metabolism
Selective Oxygen Atom Transfer to α-pinene, β-pinene, (R)-limonene and camphene by dioxo-Mo(VI)Ln complex {Ln = 2-aminothiazole-4-carboxylic acid} anchored on TiO2 nanotubes (TiO2-NT) using O2 as oxidant and UV light was studied at ambient conditions. The Catalytic system was characterized by FTIR, 1H NMR and 13C, and elemental analysis. Molecular oxygen reoxidizes the (Mo(IV)=O) reduced unit in the darkness, forming an oxo-peroxo-Mo intermediate. The catalyst under UV radiation transfers two oxygen atoms to the olefin. The α-pinene is found to be the most reactive monoterpene. Graphical Abstract: [Figure not available: see fulltext.]
Topics in Catalysis
In Colombia, young people are part of the population group that is most at risk regarding their sexual health and the knowledge associated with this component, which is why we chose to describe the sexual practices and the knowledge they have regarding HIV and other STIs, consolidating an approach to undergraduate students of an HEI in northeastern Colombia from a quantitative perspective with a non-experimental design, descriptive and cross-sectional scope. The population was 2 605 students while the sampling was probabilistic with proportional allocation resulting in a sample of 525 students, considering the 12 academic programs considered for the study. Broadly speaking, the disjunctive between the knowledge associated with STIs and the sexual practices of young university students is consolidated, and strategies should be focused on sensitizing students to strengthen healthy sexual practices that reduce their risk of acquiring STIs.
Gaceta Medica de Caracas
The present study\'s primary goal is to apply analyses of stable isotopes and tooth micro- and mesowear to the question of dietary change among a mid-Holocene population of small brocket deer (Cervidae: Mazama) in response to anthropogenic alteration of the natural insular vegetation for approximately 450 calendar years (6060-5620 cal yr BP). The brocket deer remains were found in shell-bearing middens on Pedro González in the Pearl Island archipelago. This island is the third largest of many platform or continental islands in Pacific Panama that were periodically affected by rising post-glacial seas during Pleistocene warm periods and became hills in drowned plains during glacial periods, which were extensive on the Pacific side of the isthmus. Our study is based on pre-Columbian Mazama deer remains recovered from excavations in the ancient middens of Pedro González and on modern skeletons of Mazama deer belonging to three United States museum collections. For comparative purposes we added museum specimens of extant white-tailed deer (Odocoileus virginianus) of reduced size from the Florida Keys and Coiba Island (Pacific Panama). Our results show that the diets of 1) present-day white-tailed deer from Coiba and the Florida Keys and 2) the brocket deer (Mazama) still present on San José Island were browsers. On the other hand, as soon as Preceramic people arrived on Pedro Gonzalez ca 6000 cal yr BP, the local brocket deer\'s diet gradually included more and more abrasive plants in response to changes in vegetation cover related to increasing anthropogenic clearance for cultivation.
Journal of Archaeological Science
Universidad de Santander UDES. Vigilada Mineducación.
Resolución otorgada por el Ministerio de Educación Nacional: No. 6216 del 22 de diciembre de 2005 / Personería Jurídica 810 de 12/03/96.
Institución sujeta a inspección y vigilancia por el Ministerio de Educación Nacional. Resolución 12220 de 2016.
Notificaciones administrativas y judiciales:
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